FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W865001437> ?p ?o ?g. }

• W865001437 endingPage "e0133374" @default.
• W865001437 startingPage "e0133374" @default.
• W865001437 abstract "Diabetes mellitus is a major cause of serious micro- and macrovascular diseases that affect nearly every system in the body, including the respiratory system. Non-enzymatic protein glycation due to hyperglycaemic stress has fundamental implications due to the large capillary network and amount of connective tissue in the lung. The current study was designed to determine whether leucine, zinc, and chromium supplementations influence the function and histological structure of the respiratory tract in a rat model of type 2 diabetes. Seventy-seven rats were divided into eleven groups, consisting of 7 animals each. One group served as negative control and insulin and glibenclamide were used as positive control drugs. Thus, eight groups received the nutritional supplements alone or in combination with each other. Nutritional supplements and glibenclamide were added to the drinking water and neutral protamine Hagedorn insulin was subcutaneously injected during the 4 weeks of treatment period. The induction of type 2 diabetes in the rats caused an infiltration of mononuclear cells and edema in the submucosa of the trachea and lung, severe fibrosis around the vessels and airways, and perivascular and peribronchial infiltration of inflammatory cells and fibrin. In the diabetic group, the total inflammation score and Reid index significantly increased. Diabetes induction significantly reduced the total antioxidant status and elevated the lipid peroxidation products in the serum, lung lavage and lung tissue of the diabetic animals. Treatment with nutritional supplements significantly decreased the histopathological changes and inflammatory indices in the diabetic animals. Supplementation of diabetic rats with leucine, zinc, and chromium, alone and in combination, significantly increased the total antioxidant status and lipid peroxidation level in the diabetic animals. The nutritional supplements improved the enzymatic antioxidant activity of catalase, glutathione peroxidase, myeloperoxidase, and superoxide dismutase in the diabetic rats. The present results demonstrate beneficial effects and amelioration of inflammation in the respiratory system of type 2 diabetic rats by leucine, zinc, and chromium supplements, probably due to their hypoglycaemic and antioxidant properties. Using safe and effective nutritional supplements, such as leucine, chromium and zinc, to replace proven conventional medical treatments may help to control diabetes and/or its complications." @default.
• W865001437 created "2016-06-24" @default.
• W865001437 creator A5024266645 @default.
• W865001437 creator A5071934906 @default.
• W865001437 creator A5080042946 @default.
• W865001437 creator A5086407883 @default.
• W865001437 creator A5088331000 @default.
• W865001437 creator A5088347957 @default.
• W865001437 date "2015-07-17" @default.
• W865001437 modified "2023-09-23" @default.
• W865001437 title "The Effects of Leucine, Zinc, and Chromium Supplements on Inflammatory Events of the Respiratory System in Type 2 Diabetic Rats" @default.
• W865001437 cites W140048875 @default.
• W865001437 cites W147553750 @default.
• W865001437 cites W1546592314 @default.
• W865001437 cites W1590457525 @default.
• W865001437 cites W1599342152 @default.
• W865001437 cites W1638414407 @default.
• W865001437 cites W1645450060 @default.
• W865001437 cites W1775749144 @default.
• W865001437 cites W1904938001 @default.
• W865001437 cites W191793640 @default.
• W865001437 cites W1972656394 @default.
• W865001437 cites W1973942811 @default.
• W865001437 cites W1982371325 @default.
• W865001437 cites W1987682986 @default.
• W865001437 cites W1988383120 @default.
• W865001437 cites W1998493448 @default.
• W865001437 cites W2001766097 @default.
• W865001437 cites W2010978718 @default.
• W865001437 cites W2017539238 @default.
• W865001437 cites W2020358486 @default.
• W865001437 cites W2028520543 @default.
• W865001437 cites W2030315100 @default.
• W865001437 cites W2037958045 @default.
• W865001437 cites W2057999330 @default.
• W865001437 cites W2064538040 @default.
• W865001437 cites W2066212186 @default.
• W865001437 cites W2068054275 @default.
• W865001437 cites W2068434973 @default.
• W865001437 cites W2089758826 @default.
• W865001437 cites W2093744197 @default.
• W865001437 cites W2096795975 @default.
• W865001437 cites W2110466532 @default.
• W865001437 cites W2123442091 @default.
• W865001437 cites W2125828034 @default.
• W865001437 cites W2136589902 @default.
• W865001437 cites W2138284514 @default.
• W865001437 cites W2140484793 @default.
• W865001437 cites W2141277427 @default.
• W865001437 cites W2144724140 @default.
• W865001437 cites W2148607489 @default.
• W865001437 cites W2155906147 @default.
• W865001437 cites W2161727276 @default.
• W865001437 cites W2165292984 @default.
• W865001437 cites W2165494265 @default.
• W865001437 cites W2166417278 @default.
• W865001437 cites W2169453894 @default.
• W865001437 cites W2233675681 @default.
• W865001437 cites W2336492617 @default.
• W865001437 cites W2340948203 @default.
• W865001437 cites W2403137368 @default.
• W865001437 cites W2462970827 @default.
• W865001437 cites W2614819184 @default.
• W865001437 cites W4241299322 @default.
• W865001437 cites W4243608175 @default.
• W865001437 doi "https://doi.org/10.1371/journal.pone.0133374" @default.
• W865001437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4506042" @default.
• W865001437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26185997" @default.
• W865001437 hasPublicationYear "2015" @default.
• W865001437 type Work @default.
• W865001437 sameAs 865001437 @default.
• W865001437 citedByCount "15" @default.
• W865001437 countsByYear W8650014372017 @default.
• W865001437 countsByYear W8650014372018 @default.
• W865001437 countsByYear W8650014372019 @default.
• W865001437 countsByYear W8650014372020 @default.
• W865001437 countsByYear W8650014372021 @default.
• W865001437 countsByYear W8650014372022 @default.
• W865001437 countsByYear W8650014372023 @default.
• W865001437 crossrefType "journal-article" @default.
• W865001437 hasAuthorship W865001437A5024266645 @default.
• W865001437 hasAuthorship W865001437A5071934906 @default.
• W865001437 hasAuthorship W865001437A5080042946 @default.
• W865001437 hasAuthorship W865001437A5086407883 @default.
• W865001437 hasAuthorship W865001437A5088331000 @default.
• W865001437 hasAuthorship W865001437A5088347957 @default.
• W865001437 hasBestOaLocation W8650014371 @default.
• W865001437 hasConcept C126322002 @default.
• W865001437 hasConcept C134018914 @default.
• W865001437 hasConcept C147990577 @default.
• W865001437 hasConcept C2776151105 @default.
• W865001437 hasConcept C2777180221 @default.
• W865001437 hasConcept C2777714996 @default.
• W865001437 hasConcept C2779306644 @default.
• W865001437 hasConcept C2780559512 @default.
• W865001437 hasConcept C2780829032 @default.
• W865001437 hasConcept C555293320 @default.
• W865001437 hasConcept C71924100 @default.

• next