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- W865283048 endingPage "2060" @default.
- W865283048 startingPage "2056" @default.
- W865283048 abstract "目的:研究intermedin1-53(IMD1-53)对醛固酮(ALD)促SD乳鼠心肌成纤维细胞(CFBs)增殖的影响及细胞外信号调节激酶(ERK)信号转导途径的作用。方法:分离培养SD乳鼠CFBs,将细胞分成对照组、不同浓度ALD组、ALD+不同浓度IMD1-53组,用MTT比色法测定细胞活性。通过Western blotting方法观察IMD1-53对ALD诱导的p-ERK蛋白表达的影响。结果:(1)IMD1-53对基础状态下的CFBs增殖无明显抑制作用,但能呈浓度(10-9~10-7mol/L)依赖性地抑制ALD刺激CFBs的增殖。(2)IMD1-53具有浓度(10-9~10-7mol/L)依赖性地抑制ALD诱导的p-ERK蛋白表达的作用。结论:IMD1-53通过ERK信号途径抑制ALD促CFBs增殖的效应。" @default.
- W865283048 created "2016-06-24" @default.
- W865283048 creator A5027783077 @default.
- W865283048 date "2011-11-15" @default.
- W865283048 modified "2023-09-23" @default.
- W865283048 title "Intermedin 1-53 对大鼠心肌成纤维细胞增殖的影响" @default.
- W865283048 doi "https://doi.org/10.3969/j.issn.1000-4718.2011.11.002" @default.
- W865283048 hasPublicationYear "2011" @default.
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