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- W8653608 abstract "528 Objectives: To improve accuracy of preoperative localization of parathyroid adenomas (PA). To facilitate minimally invasive surgical approach to PA, as opposed to open cervicotomy and bilateral neck exploration. Methods: MRI and SPECT images were acquired on the same patients with fiducial skin markers (FSMs) placed on patient’s thorax and neck. MRI was performed with a 3T magnet using T2-weighted spin-echo sequences. SPECT images were acquired: (i) 1 mCi of Tc-99m pertechnetate; (ii) 15 min. and (iii) 120 min. after administration of 30 mCi of Tc-99m sestamibi. A deformable finite element model (FEM) has been implemented for accurate nonrigid registration and fusion of SPECT and MRI images. In this model FSMs are used to sample 3D image deformation between SPECT and MRI. In this approach first the intermodality displacements of the corresponding FSMs observed in SPECT and MRI are determined, then FEM is used to distribute the FSMs displacements linearly over the entire volume, followed by creation of a warped MR image registered with the SPECT image and by MRI and SPECT volume fusion. ANSYS FEM software was used for FEM calculations along with our own programs for 3D image warping and fusion. Results: Using organs with known high uptake of radiopharmaceuticals we verified correct anatomical intermodal registration of the fused SPECT/MRI images with target registration error not exceeding 4 mm. Conclusions: Application of our fusion and registration method allowed creation of a detailed anatomic map of the neck/thorax from MRI accurately combined with a functional map from SPECT for improved preoperative localization of the parathyroid adenomas. Research Support (if any): SUNY Upstate Medical University Pilot Grant" @default.
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- W8653608 date "2007-05-01" @default.
- W8653608 modified "2023-09-23" @default.
- W8653608 title "Fusion of SPECT and MRI images for improved localization of parathyroid adenomas in patients with persistent or recurrent hyperparathyroidism" @default.
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