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• W86613608 abstract "OBJECTIVE: To determine if essential tremor is associated with an increased risk of dementia. BACKGROUND: Previous population studies in the elderly have suggested that patients with tremor might be at higher risk for incident dementia when followed longitudinally. DESIGN/METHODS: Subjects without dementia or a neurodegenerative movement disorder at study entry, and who had at least one follow-up visit, were selected from the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND) database. The incidence of dementia in subjects with ET was compared to that of Controls using Cox regression. RESULTS: There were 90 subjects with ET and 432 subjects without ET. The proportion of women was lower in the ET group (44% versus 70%). Age at study entry ranged from 45 to 100 years. Mean age was not substantially higher in the ET group (79.9 years vs. 77.1 for controls). ApoE genotype was known for 58 subjects in the ET group and 250 subjects in the Control group. The proportion of ApoE e4 carriers was not substantially different in the ET group (19% vs. 25%). Age at ET onset ranged from 0 to 90 years (mean 67, SD 19), and the duration of ET at study entry ranged from 0 to 72 years (mean 12, SD 18). The incidence of dementia was not higher in the ET group than in the Control group. The incidence of dementia within 5 years of study entry was 11% for both ET and Control groups (95% CI 4% to 17% for ET, and 8% to 14% for Control). The hazard ratio for the association between ET and dementia was 0.97 (95% CI 0.50 to 1.9). Adjustment for age, sex, and e4 status did not increase the hazard ratio for the association between ET and dementia. CONCLUSIONS: ET is not associated with increased risk of dementia in this longitudinal aging study. Supported by: International Essential Tremor Foundation. The operation of the Banner Sun Health Research Institute Brain and Body Donation Program is supported by the National Institute of Neurological Disorders and Stroke (U24 NS072026 National Brain and Tissue Resource for Parkinson9s Disease and Related Disorders), the National Institute on Aging (P30 AG19610 Arizona Alzheimer9s Disease Core Center), the Arizona Department of Health Services (contract 211002, Arizona Alzheimer9s Research Center), the Arizona Biomedical Research Commission (contracts 4001, 0011, 05-901 and 1001 to the Arizona Parkinson9s Disease Consortium) and the Michael J. Fox Foundation for Parkinson9s Research (The Prescott Family Initiative). Disclosure: Dr. Shill has received personal compensation for activities with Lundbeck and Merz Pharmaceuticals for serving on advisory boards. Dr. Shill has received reseasrch support from Chelsea Therapeutics, Teva Neuroscience, Schering-Plough Research Institute, Adamas, Allergan, and Avid Radiopharmaceuticals. ......Forest Laboratories, Inc: Nebivolol and inappropriate left ventricular mass. Eisai Inc.: Lusedra for sedation during regional anesthesia block. Caridian: Maintenance plasma exchange for neuromyelitis optica spectrum disorders. Millennium: CyBorD in multiple myeloma. Dr. Belden has received research support from Celgene, Quintiles/Genentech, Inc., Avid, Eli Lilly & Company, GE Healthcae, Wyeth Pharmaceuticals, Bayer Pharmaceuticals Corporation, and Pfizer Inc. Dr. Powell has received research support from Quintiles/Genentech, Pfizer, Celgene, and AVID. Dr. Jacobson has received research support from Avid, Baxter, Bayer, Bristol-Myers Squibb Company, Celgene, Eisai Inc, Elan Corporation, Eli Lilli & Company, General Electric, Genentech, Inc., Janssen, and Pfizer Inc. Dr. Sabbagh has received personal compensation for activities with Amerisciences, Pfizer, Eisai, Lilly, Avid, BMS, Allon. Dr. Sabbagh has received royalty payments from Amerisciences for the development of Cognivite Complete and Wiley. Dr. Sabbagh has received research support from Avid, Baxter, Bayer, BMS, Celgene, Eisai, Elan, Eli Lilly, GE, Genentech, Janssen/Wyeth, and Pfizer. Dr. Caviness has received research support from Amarin Pharmaceuticals. Dr. Beach has received research support from Avid Radiopharmaceuticals/Eli Lilly Corporation, Bayer Healthcare, GE Healthcare, GlaxoSmithKline, Inc., Elan Corporation, Janssen, Iperian, Signum, Biogen Idec, HTG Molecular and Neotope. Dr. Adler has received personal compensation for activities with Ipsen, Merz Pharma, and Impax. Dr. Adler has received research support from Avid Radiopharmaceuticals and Phytopharm." @default.
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• W86613608 date "2013-02-12" @default.
• W86613608 modified "2023-09-25" @default.
• W86613608 title "Risk of Developing Dementia in Essential Tremor (S53.004)" @default.
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