FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W866209724> ?p ?o ?g. }

• W866209724 endingPage "e0132656" @default.
• W866209724 startingPage "e0132656" @default.
• W866209724 abstract "Dry eye complaints are ranked as the most frequent symptoms of patients visiting ophthalmologists. Conjunctivochalasis is a common dry eye disorder, which can cause an unstable tear film and ocular discomfort. The severe conjunctivochalasis characterized by high LId-Parallel COnjunctival Folds (LIPCOF) degree usually requires surgical intervention, where a conservative therapy would be highly desirable. Here we examined the efficacy of a preservative-free, inorganic salt-free unit-dose artificial tear, called Conheal containing isotonic glycerol and 0.015% sodium hyaluronate in a prospective, unmasked, self-controlled study involving 20 patients. The regular use of the glycerol/hyaluronate artificial tear in three months caused a significant improvement in the recorded parameters. Conjunctivochalasis decreased from a mean LIPCOF degree of 2.9±0.4 on both eyes to 1.4±0.6 on the right (median decrease of -2 points, 95% CI from -2.0 to -1.0), and to 1.4±0.7 on the left eye (median decrease of -1 points, 95% CI from -2.0 to -1.0) (p<0.001 for both sides). The tear film breakup time (TFBUT) lengthened from 4.8±1.9 seconds on both eyes to 5.9±2.3 seconds (mean increase of 1.1 seconds, 95% CI from 0.2 to 2.0) and 5.7±1.8 seconds (mean increase of 0.9 seconds, 95% CI from 0.3 to 1.5) on the right and left eyes, respectively (pright eyes = 0.020, pleft eyes = 0.004). The corneal lissamine staining (Oxford Scheme grade) was reduced from 1.3±0.6 on the right and 1.4±0.6 on the left eye significantly (p<0.001) to 0.3±0.4 and 0.2±0.4 on the right and the left eyes. The Ocular Surface Disease Index (OSDI) questionnaire score indicating the subjective complaints of the patients also decreased from a mean value of 36.2±25.3 to 15.6±16.7 (p<0.001). In this study, the artificial tear, Conheal decreased the grade of the conjunctivochalasis significantly after one month of regular use already, from the LIPCOF degree 3, considered as indication of conjunctival surgery, to a LIPCOF degree 2 or lower requiring a conservative therapy. Our results raise the possibility that vision-related quality of life can be significantly improved by conservative therapies even in severe conjunctivochalasis. Trial Registration Controlled-Trials.com ISRCTN81112701 http://www.isrctn.com/ISRCTN81112701" @default.
• W866209724 created "2016-06-24" @default.
• W866209724 creator A5052810715 @default.
• W866209724 creator A5061111357 @default.
• W866209724 date "2015-07-14" @default.
• W866209724 modified "2023-10-14" @default.
• W866209724 title "Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study" @default.
• W866209724 cites W169178642 @default.
• W866209724 cites W172748708 @default.
• W866209724 cites W1969956598 @default.
• W866209724 cites W1969980370 @default.
• W866209724 cites W1984047531 @default.
• W866209724 cites W1989051743 @default.
• W866209724 cites W1990509643 @default.
• W866209724 cites W1991223802 @default.
• W866209724 cites W1999087730 @default.
• W866209724 cites W2008286079 @default.
• W866209724 cites W2024383173 @default.
• W866209724 cites W2027388876 @default.
• W866209724 cites W2028300497 @default.
• W866209724 cites W2031440912 @default.
• W866209724 cites W2035112487 @default.
• W866209724 cites W2037551235 @default.
• W866209724 cites W2040890098 @default.
• W866209724 cites W2053390580 @default.
• W866209724 cites W2055370551 @default.
• W866209724 cites W2056800593 @default.
• W866209724 cites W2057852734 @default.
• W866209724 cites W2062777714 @default.
• W866209724 cites W2070739493 @default.
• W866209724 cites W2081076872 @default.
• W866209724 cites W2083016743 @default.
• W866209724 cites W2085658657 @default.
• W866209724 cites W2091630088 @default.
• W866209724 cites W2095486779 @default.
• W866209724 cites W2114928809 @default.
• W866209724 cites W2126399616 @default.
• W866209724 cites W2163661438 @default.
• W866209724 cites W2184413367 @default.
• W866209724 cites W2335549822 @default.
• W866209724 cites W2396804078 @default.
• W866209724 cites W2417562978 @default.
• W866209724 cites W2432725189 @default.
• W866209724 cites W2596391620 @default.
• W866209724 cites W2751545921 @default.
• W866209724 cites W52951279 @default.
• W866209724 cites W98061393 @default.
• W866209724 doi "https://doi.org/10.1371/journal.pone.0132656" @default.
• W866209724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4501551" @default.
• W866209724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26172053" @default.
• W866209724 hasPublicationYear "2015" @default.
• W866209724 type Work @default.
• W866209724 sameAs 866209724 @default.
• W866209724 citedByCount "17" @default.
• W866209724 countsByYear W8662097242017 @default.
• W866209724 countsByYear W8662097242018 @default.
• W866209724 countsByYear W8662097242019 @default.
• W866209724 countsByYear W8662097242021 @default.
• W866209724 countsByYear W8662097242022 @default.
• W866209724 countsByYear W8662097242023 @default.
• W866209724 crossrefType "journal-article" @default.
• W866209724 hasAuthorship W866209724A5052810715 @default.
• W866209724 hasAuthorship W866209724A5061111357 @default.
• W866209724 hasBestOaLocation W8662097241 @default.
• W866209724 hasConcept C118487528 @default.
• W866209724 hasConcept C126322002 @default.
• W866209724 hasConcept C141071460 @default.
• W866209724 hasConcept C2777917749 @default.
• W866209724 hasConcept C2778275304 @default.
• W866209724 hasConcept C2778837293 @default.
• W866209724 hasConcept C71924100 @default.
• W866209724 hasConcept C77056095 @default.
• W866209724 hasConceptScore W866209724C118487528 @default.
• W866209724 hasConceptScore W866209724C126322002 @default.
• W866209724 hasConceptScore W866209724C141071460 @default.
• W866209724 hasConceptScore W866209724C2777917749 @default.
• W866209724 hasConceptScore W866209724C2778275304 @default.
• W866209724 hasConceptScore W866209724C2778837293 @default.
• W866209724 hasConceptScore W866209724C71924100 @default.
• W866209724 hasConceptScore W866209724C77056095 @default.
• W866209724 hasIssue "7" @default.
• W866209724 hasLocation W8662097241 @default.
• W866209724 hasLocation W8662097242 @default.
• W866209724 hasLocation W8662097243 @default.
• W866209724 hasLocation W8662097244 @default.
• W866209724 hasLocation W8662097245 @default.
• W866209724 hasLocation W8662097246 @default.
• W866209724 hasLocation W8662097247 @default.
• W866209724 hasLocation W8662097248 @default.
• W866209724 hasOpenAccess W866209724 @default.
• W866209724 hasPrimaryLocation W8662097241 @default.
• W866209724 hasRelatedWork W1991303443 @default.
• W866209724 hasRelatedWork W2060033748 @default.
• W866209724 hasRelatedWork W2092842778 @default.
• W866209724 hasRelatedWork W2156627811 @default.
• W866209724 hasRelatedWork W2326399301 @default.
• W866209724 hasRelatedWork W2331370299 @default.
• W866209724 hasRelatedWork W2587436937 @default.

• next