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- W866949917 abstract "Current environmental regulations relating to risk assessment for contaminated sites are often set assuming that the contaminant is 100% bioavailable. It is therefore not surprising that remediation of contaminated sites is very expensive and maybe it is unrealistic to achieve a “remediated state” under current regulatory guidelines using existing technologies. In fact the reality is that only a portion of the contaminant on site becomes available for absorption and goes into the systemic circulation. This article gives an overview of existing in vivo animal models that quantify oral bioavailability of polycyclic aromatic hydrocarbons (PAHs) in soil. It also provides a summary of in vitro gastrointestinal extraction methodologies and some of the key factors influencing absorption of PAHs in soil. For innovation, it highlights that bioaccessibility values derived from in vitro studies still require validation from in vivo animal models to gain regulatory acceptance. Additionally, this review highlights the use of non-exhaustive chemical methodologies as a valuable tool to understanding the bioavailability process and behaviour of PAHs in soil." @default.
- W866949917 created "2016-06-24" @default.
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- W866949917 date "2015-10-01" @default.
- W866949917 modified "2023-09-26" @default.
- W866949917 title "A review of non-exhaustive chemical and bioavailability methods for the assessment of polycyclic aromatic hydrocarbons in soil" @default.
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- W866949917 doi "https://doi.org/10.1016/j.eti.2015.07.001" @default.
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