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• W867580237 abstract "Epidemiological data suggest a link between food allergies and the subsequent development of asthma. Although this progression may result from the additional effects of exposure to multiple allergens, whether both allergies amplify each other's effects remains unknown. This study investigated whether oral exposure to food allergens influences the outcomes of subsequent respiratory exposure to an asthma-inducing allergen. Mice were sensitized and orally challenged with wheat (FA) and then exposed to house dust mite (HDM) extract (RA). Immunoglobulin (Ig), histamine, and cytokine levels were assayed by ELISA. Intestinal and lung physiology was assessed. Ig levels, histamine release, and cytokine secretion were higher after exposure to both allergens than after separate exposure to each. Intestinal permeability was higher, although airway hyper-responsiveness and lung inflammation remained unchanged. Exposure to food and respiratory allergens amplifies systemic and gut allergy-related immune responses without any additional effect on lung function and inflammation." @default.
• W867580237 created "2016-06-24" @default.
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• W867580237 date "2015-07-14" @default.
• W867580237 modified "2023-09-30" @default.
• W867580237 title "Consecutive Food and Respiratory Allergies Amplify Systemic and Gut but Not Lung Outcomes in Mice" @default.
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• W867580237 doi "https://doi.org/10.1021/acs.jafc.5b02338" @default.
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