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- W86771126 abstract "The term osteomalacia describes a disorder of adult bone. This chapter reviews adult osteomalacia with a primary focus on its antecedents. It describes the clinical settings in which osteomalacia likely occurs and briefly summarizes elements of diagnosis and management of this condition. To begin, it briefly summarizes normal bone mineralization and the disruptions in this process that lead to osteomalacia. Successful therapy of osteomalacia requires elimination of its underlying factors in individual cases. This chapter illustrates that where osteomalacia is based on excessive exposure to fluoride, etidronate, or non absorbable antacids, the offending exposure must be terminated. Unfortunately, the skeletal half-life of fluoride and bisphosphonate is long, and resolution of osteomalacia may require years of follow-up. Such patients do respond, at least partially, to vitamin D and calcium therapy. Aluminum excess is successfully treated by infusions of desferroxamine." @default.
- W86771126 created "2016-06-24" @default.
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- W86771126 date "2001-01-01" @default.
- W86771126 modified "2023-10-16" @default.
- W86771126 title "Osteomalacia" @default.
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- W86771126 doi "https://doi.org/10.1016/b978-012193155-1/50048-9" @default.
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