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• W8677598 abstract "This chapter discusses the hormonal control of ovarian follicular development. The growth of a follicle appears to begin with the growth of the primary oocyte, its enclosure within a single layer of granulosa cells, the formation of a basement membrane, and the attachment of surrounding theca cells. In the presence of gonadotropins, however, follicular growth continues until large preantral and antral follicles are developed. Most stages of follicular growth appear to proceed in the presence of basal concentrations of gonadotropins. Thus, during pregnancy antrai follicles are continuously present as new groups of follicles acquire antra and others undergo atresia. The hormonal requirements for the continued growth of follicles to the preovulatory stage appear to involve small but significant increases in gonadotropins, leading to increased synthesis of follicular androgens and estradiol. During the maturation of preovulatory follicles, receptor for LH in theca cells is increased 2- to 3-fold and is accompanied by an increased synthesis of androgens. As some aromatase activity is present in the small antral follicles, the increase in androgen leads automatically to an increase in some estradiol production. Thus, a change in theca cell function and responsiveness to LH appears to precede increased follicular estradiol synthesis. During the estrous cycle and at the end of pregnancy, the final stages of preovulatory follicular growth are dependent on increased estradiol synthesis. This appears to be dependent on increased responsiveness of theca cells to LH and increased production of theca-derived androgens. Thus, the theca cell may hold the clue to what initiates preovulatory follicular growth." @default.
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• W8677598 date "1979-01-01" @default.
• W8677598 modified "2023-09-25" @default.
• W8677598 title "Hormonal Control of Ovarian Follicular Development: A 1978 Perspective" @default.
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• W8677598 doi "https://doi.org/10.1016/b978-0-12-571135-7.50012-6" @default.
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