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• W86791041 endingPage "75" @default.
• W86791041 startingPage "57" @default.
• W86791041 abstract "B-cell chronic lymphocytic leukemia (B-CLL) is the most frequent type of leukemia among adults in the Western world, with an incidence of about 5 cases per 100,000 residents annually (1,2). The disease affects mainly people of advanced age, but about 20% of patients are younger than 55 (3).B-CLL is characterized by the accumulation of lymphocytes that appear morphologically mature but are functionally incompetent in bone marrow, blood, lymph nodes, and other organs, primarily of the lymphatic system (Fig. 1). During the course of the disease, there is increasing suppression of normal hematopoiesis and impairment of organ functions, resulting in B-symptoms, susceptibility to infection, and hemorrhage (Fig. 1). Currently available conventional therapeutic procedures are aimed at palliation. In younger patients, potentially curative approaches like autologous or allogeneic stem cell transplantation and antibody therapies are currently being investigated. The prognosis is influenced by the degree of dissemination of the disease at the time of diagnosis. This is reflected in the prognostic importance of the clinical staging systems defined by Rai and Binet (4,5).Both systems differentiate among early (Rai 0, Binet A), intermediate (Rai I, II; Binet B) and advanced (Rai III, IV; Binet C) stages, which are characterized by different survival times (Fig. 2) (6).However, the prognostic value of clinical staging is limited, especially in early stages, and there is marked heterogeneity in the speed of disease progression within the individual stages. For this reason, there has been intensive work in recent years on the identification of other clinical and biological factors with potential prognostic relevance. Genetic characteristics of the B-CLL cells have attained considerable importance among these factors (7–10)." @default.
• W86791041 created "2016-06-24" @default.
• W86791041 creator A5010582324 @default.
• W86791041 creator A5019866348 @default.
• W86791041 creator A5089395073 @default.
• W86791041 date "2004-01-01" @default.
• W86791041 modified "2023-09-25" @default.
• W86791041 title "Genetics of B-Cell Chronic Lymphocytic Leukemia" @default.
• W86791041 cites W117448714 @default.
• W86791041 cites W122353466 @default.
• W86791041 cites W1243376384 @default.
• W86791041 cites W1429374962 @default.
• W86791041 cites W146673805 @default.
• W86791041 cites W1484187172 @default.
• W86791041 cites W1525886108 @default.
• W86791041 cites W1527161131 @default.
• W86791041 cites W154103547 @default.
• W86791041 cites W1552162287 @default.
• W86791041 cites W1564039428 @default.
• W86791041 cites W1603333513 @default.
• W86791041 cites W167225159 @default.
• W86791041 cites W185768814 @default.
• W86791041 cites W1923636344 @default.
• W86791041 cites W1933514140 @default.
• W86791041 cites W1965851569 @default.
• W86791041 cites W1968123077 @default.
• W86791041 cites W1968572217 @default.
• W86791041 cites W1970453241 @default.
• W86791041 cites W1970584505 @default.
• W86791041 cites W1971096058 @default.
• W86791041 cites W1972018315 @default.
• W86791041 cites W1973841275 @default.
• W86791041 cites W1975100378 @default.
• W86791041 cites W1975213851 @default.
• W86791041 cites W1977382048 @default.
• W86791041 cites W1979000512 @default.
• W86791041 cites W1979787390 @default.
• W86791041 cites W1981885433 @default.
• W86791041 cites W1982634023 @default.
• W86791041 cites W1993659376 @default.
• W86791041 cites W1995058374 @default.
• W86791041 cites W1998679425 @default.
• W86791041 cites W1998770107 @default.
• W86791041 cites W1999330214 @default.
• W86791041 cites W2001358796 @default.
• W86791041 cites W2005566446 @default.
• W86791041 cites W2005705780 @default.
• W86791041 cites W2006486191 @default.
• W86791041 cites W2009967055 @default.
• W86791041 cites W2010667317 @default.
• W86791041 cites W2015116446 @default.
• W86791041 cites W2022012268 @default.
• W86791041 cites W2026805676 @default.
• W86791041 cites W2028008767 @default.
• W86791041 cites W2029898658 @default.
• W86791041 cites W2037049243 @default.
• W86791041 cites W2045366639 @default.
• W86791041 cites W2046589688 @default.
• W86791041 cites W2049819517 @default.
• W86791041 cites W2056163856 @default.
• W86791041 cites W2057269176 @default.
• W86791041 cites W2057523745 @default.
• W86791041 cites W2058587900 @default.
• W86791041 cites W2066668872 @default.
• W86791041 cites W2067603983 @default.
• W86791041 cites W2068909560 @default.
• W86791041 cites W2069284895 @default.
• W86791041 cites W2078673385 @default.
• W86791041 cites W2080951919 @default.
• W86791041 cites W2082030057 @default.
• W86791041 cites W2084479574 @default.
• W86791041 cites W2085666673 @default.
• W86791041 cites W2085747103 @default.
• W86791041 cites W2086858152 @default.
• W86791041 cites W2086950890 @default.
• W86791041 cites W2089835533 @default.
• W86791041 cites W2090199761 @default.
• W86791041 cites W2094423664 @default.
• W86791041 cites W2095387136 @default.
• W86791041 cites W2097803333 @default.
• W86791041 cites W2099348990 @default.
• W86791041 cites W2101719051 @default.
• W86791041 cites W2104235597 @default.
• W86791041 cites W2111609050 @default.
• W86791041 cites W2124604393 @default.
• W86791041 cites W2129292278 @default.
• W86791041 cites W2130436812 @default.
• W86791041 cites W2134774489 @default.
• W86791041 cites W2142621472 @default.
• W86791041 cites W2146800367 @default.
• W86791041 cites W2148656577 @default.
• W86791041 cites W2152380453 @default.
• W86791041 cites W2152644051 @default.
• W86791041 cites W2156131696 @default.
• W86791041 cites W2156169904 @default.
• W86791041 cites W2164503950 @default.
• W86791041 cites W2170828133 @default.
• W86791041 cites W2172092345 @default.

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