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- W86796645 abstract "Effectiveness of 2-year treatment of hirsutism with low estrogen oral contraceptives (OCs) containing nonandrogenic or antiandrogenic progestogen. Evaluation of changes in plasma lipids. Ten patients treated with desogestrel 150 μg + 30 μg ethinyl estradiol, 6 with desogestrel 150 μg + 50 μg ethinyl estradiol, 10 with cyproterone acetate 2 mg + 35 μg ethinyl estradiol. Random allocation. Paired comparisons. Control group: 19 normal women, not treated. Academic tertiary care. Women with hirsutism (idiopathic and/or polycystic ovary), 24 of 26 completed treatment. Two-year treatment. Hirsutism score, plasma testosterone, and lipids. Initial hirsutism scores (11.8 ± 0.6 SE) declined with treatment (− 7.2 ± 0.4, P < 0.01) to 4.7 ± 0.6, almost reaching control (3.6 ± 0.3). Initial plasma cholesterol (4.33 mmol/L ± 0.30 SE), similar to control (4.78 ± 0.24), increased slowly over 2 years (+ 2.04 ± 0.34, P < 0.01). High-density lipoproteins cholesterol (1.05 mmol/L ± 0.04 SE), similar to control (1.12 ± 0.07), did not change the 1st year and increased at 2 years (+ 0.57 ± 0.11, P < 0.01). No differences appeared among treatment groups. Treatment is very effective, 2 years for best results. The OCs tested are equally efficacious. Changes in plasma lipids are of some concern but of difficult interpretation." @default.
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- W86796645 title "Long-term treatment of hirsutism: desogestrel compared with cyproterone acetate in oral contraceptives" @default.
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- W86796645 doi "https://doi.org/10.1016/s0015-0282(16)54291-5" @default.
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