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• W86875131 abstract "Research Article1 February 1996free access Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. N. Tokai N. Tokai The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author A. Fujimoto-Nishiyama A. Fujimoto-Nishiyama The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author Y. Toyoshima Y. Toyoshima The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author S. Yonemura S. Yonemura The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author S. Tsukita S. Tsukita The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author J. Inoue J. Inoue The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author T. Yamamota T. Yamamota The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author N. Tokai N. Tokai The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author A. Fujimoto-Nishiyama A. Fujimoto-Nishiyama The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author Y. Toyoshima Y. Toyoshima The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author S. Yonemura S. Yonemura The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author S. Tsukita S. Tsukita The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author J. Inoue J. Inoue The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author T. Yamamota T. Yamamota The Institute of Medical Science, The University of Tokyo, Japan. Search for more papers by this author Author Information N. Tokai1, A. Fujimoto-Nishiyama1, Y. Toyoshima1, S. Yonemura1, S. Tsukita1, J. Inoue1 and T. Yamamota1 1The Institute of Medical Science, The University of Tokyo, Japan. The EMBO Journal (1996)15:457-467https://doi.org/10.1002/j.1460-2075.1996.tb00378.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Microtubule-associated motor proteins are thought to be involved in spindle formation and chromosome movements in mitosis/meiosis. We have molecularly cloned cDNAs for a gene that codes for a novel member of the kinesin family of proteins. Nucleotide sequencing reveals that the predicted gene product is a 73 kDa protein and is related to some extent to the Drosophila node gene product, which is involved in chromosomal segregation during meiosis. A sequence similar to the microtubule binding motor domain of kinesin is present in the N-terminal half of the protein, and its ability to bind to microtubules is demonstrated. Furthermore we show that its C-terminal half contains a putative nuclear localization signal similar to that of Jun and is able to bind to DNA. Accordingly, the protein was termed Kid (kinesin-like DNA binding protein). Indirect immunofluorescence studies show that Kid colocalizes with mitotic chromosomes and that it is enriched in the kinetochore at anaphase. Thus, we propose that Kid might play a role(s) in regulating the chromosomal movement along microtubules during mitosis. Previous ArticleNext Article Volume 15Issue 31 February 1996In this issue RelatedDetailsLoading ..." @default.
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• W86875131 title "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle." @default.
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• W86875131 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00378.x" @default.
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