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- W868938961 abstract "A series of new flavanone derivatives of farrerol was designed and synthesized as a potent inhibitor of vascular smooth muscle cells(VSMCs) vegetation according to a convenient method. The structures of all the synthe- sized compounds were confirmed by 1 H NMR, 13 C NMR and EIHR-MS. The biological activities of these compounds against VSMCs in vitro were evaluated. The assay results indicate that two compounds, 5,7-dihydroxy-6,8-dimethyl- 2-(2-nitrophenyl)chroman-4-one(7f) and 2,3-dibromo-4,5-dihydroxydiphenylmethanone(7j) exhibited high activity against VSMCs in vitro with IC50 values of 9.9 and 6.7 μmol/L, respectively, and the preliminary structure-activity relationship(SAR) was described. Keywords Synthesis; Flavanone derivative; Anti-VSMCs vegetation Article ID 1005-9040(2011)-02-237-04" @default.
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- W868938961 date "2011-01-01" @default.
- W868938961 modified "2023-09-25" @default.
- W868938961 title "Synthesis of New Flavanone Derivatives of Farrerol and Preliminary SAR Studies on Anti-VSMCs Vegetation Activity" @default.
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