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- W869438964 abstract "The endocytic pathway tightly regulates the activity of G protein-coupled receptors (GPCRs). Much of our understanding of this relationship between GPCR endocytic trafficking and signaling comes from studies done on catecholamine and opioid receptors. After ligand-induced endocytosis, a key sorting step in the endosome determines whether receptors are recycled back to the cell surface, leading to recovery of signaling, or are degraded in the lysosome, leading to desensitization. Recycling of GPCRs, unlike that of many other proteins, is an active process driven by specific sequences on the receptor and proteins that interact with this sequence. Recent data suggest that sequence-dependent recycling plays complex roles in regulating both the timing and location of GPCR signaling. This chapter will describe our current understanding of the mechanisms regulating GPCR sorting in the endosome and discuss emerging ideas on their role in GPCR signaling, focusing on adrenergic and opioid receptors as prototypes." @default.
- W869438964 created "2016-06-24" @default.
- W869438964 creator A5007160724 @default.
- W869438964 creator A5018983964 @default.
- W869438964 date "2015-01-01" @default.
- W869438964 modified "2023-09-27" @default.
- W869438964 title "Postendocytic Sorting of Adrenergic and Opioid Receptors" @default.
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