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• W8708164 abstract "Objective: The aim of this pa- per is to evaluate the effect of atorvastatin on bone mineral density in patients with acute is- chemic heart disease. Matherial and Methods: Eighty-three pa- tients (52 male and 31 female) with acute coro- nary syndrome were studied. They received treatment with atorvastatin using low doses (20 mg) and high doses (40 mg-80 mg). Initial and fi- nal cholesterol, triglyceride, calcium, phospho- rus, 25-hydroxyvitamin D were obtained from every patient. Spine and hip bone mineral densi- ty were performed at the beginning and one year later. Results: Atorvastatin treatment increases vit- amin D (33%, p = 0.007) and decreases the indi- viduals with vitamin D insufficiency. Bone miner- al density increased in the spine (1.31%, p = 0.02), but it was significant only in male and pa- tients presenting vitamin D levels higher than 30 nmol/l. Conclusion: Atorvastatin has a beneficial ef- fect on bone metabolism in patients with acute ischemic heart disease (mainly males) by incre- menting bone mineral density in which vitamin D levels are required to be higher than 30 nmol/l for the drug to be effective." @default.
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• W8708164 date "2008-03-01" @default.
• W8708164 modified "2023-10-09" @default.
• W8708164 title "Effect of atorvastatin on bone mineral density in patients with acute coronary syndrome." @default.
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