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- W87086022 abstract "espanolEl conocimiento sobre marcadores tumorales ha permitido un mejor entendimiento del comportamiento de las neoplasias. Uno de los marcadores mejor estudiados es el oncogen HER 2 NEU el cual se ha relacionado como elemento pronostico y predictivo en cancer de mama lo que motivo a investigar la frecuencia de sobre expresion del Her2 en una serie consecutiva de casos de carcinoma ductal invasor. Se estudio la expresion inmunohistoquimica del HER 2 NEU mediante el uso del HERCEP TEST de DAKO, en 1708 casos consecutivos de carcinoma ductales invasores Paralelamente estos datos se correlacionaron con algunos datos clinicos como: edad, sexo, mama afectada y con ciertos hallazgos histopatologicos como: grado de diferenciacion tumoral, invasion vascular, invasion peri neural y compromiso ganglionar. Se obtuvo una frecuencia de 16,29 % de casos HER 2 Neu positivos, 6,51% dudosos y 77,20% negativos. No observamos relaciones significativas entre grado de diferenciacion tumoral, invasion vascular y perineural y el estatus del HER 2 NEU, pero si se obtuvo una relacion positiva entre los resultados de este marcador y el compromiso ganglionar. EnglishAssessment of human epidermal growth factor receptor-2 status is standard practice in women with breast cancer. Molecular markers are studied for their potential to act as prognostic or predictive factors. A prognostic factor influences the clinical outcome independently of treatment, whereas a predictive factor correlates with prognosis because it is linked to the response to a particular therapy. HER2 may function as both a prognostic and a predictive factor. This study was undertaken to validate HERCEPTEST (DAKO) as a method for assessing human epidermal growth factor receptor-2 gene amplification. We evaluated consecutive 1708 specimens with invasive breast carcinoma, correlated with age, gender and involved gland. Additional, were correlated with histological differentiation grade, vascular and perineural invasion and nodal status. RESULTS: Her 2 Neu positive in 16, 29 % of cases (score +3), negative in 77, 2% (score 0/+1) and 6, 51% were scored as 2+. We didn't founded relationship between grade of histological differentiation, vascular and neural invasion and Her 2 Neu status. Nevertheless, status nodal was associated with Her 2 Neu expression." @default.
- W87086022 created "2016-06-24" @default.
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- W87086022 date "2012-01-01" @default.
- W87086022 modified "2023-09-27" @default.
- W87086022 title "Expresión inmunohistoquímica del oncogen her2 neu en pacientes con carcinoma ductal" @default.
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