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- W870945747 abstract "The protective effect fDDB against carcinogen-induced DNA damage was examined in the present investigation.Preincubation of rat liver nuclei with DDB(1mmol·L^-1)resulted in 60% inhibition of binding of ^3H-benzo(a)pyrene to nuclear DNA.unscheduled DNA synthesis(UDS)induced by aflatoxin B1(10^-7mol·L^-1) in freshly isolated rat hepatocytes was also inhibited by DDB(10^-6-10^-3mol·L^-1).Oral administation of DDB at 200mg·k^-1once daily for 3 d induced a significant increase of liver cytosol glutathione-S-transferase and microsomal UDPG-transferase activity in mice.These results indicate that DDB is able to directly or indirectly antagonize certain carcinogen-induced DNA damages." @default.
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- W870945747 date "1992-01-01" @default.
- W870945747 modified "2023-09-26" @default.
- W870945747 title "Protective Eff4ect of Dimethyl—4,4‘—Dimethoxy—5,6,5’,6‘—Dimethylene Dioxybiphenyl—2,2’—Dicarboxylate（DDB）against Carcinogen—Induced Rat Liver Nuclear DNA Damage" @default.
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