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• W8711136 abstract "No AccessJournal of Urology1 May 1987Priapism Induced by Chlorpromazine and Trazodone: Mechanism of Action Jason C. Abber, Tom F. Lue, Jian-An Luo, Klaus-Peter Juenemann, and Emil A. Tanagho Jason C. AbberJason C. Abber More articles by this author , Tom F. LueTom F. Lue More articles by this author , Jian-An LuoJian-An Luo More articles by this author , Klaus-Peter JuenemannKlaus-Peter Juenemann More articles by this author , and Emil A. TanaghoEmil A. Tanagho More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)44355-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail To investigate the mechanism of drug-induced priapism, we gave the antipsychotic agent chlorpromazine and the antidepressant trazodone to 14 dogs by intravenous and intracorporeal injection. Bilateral intracorporeal pressure, blood flow within the internal pudendal artery, and systemic blood pressure were monitored. Venous outflow restriction was evaluated by continuous saline infusion of the corpus cavernosum with the infrarenal aorta clamped. When delivered by intracorporeal injection, both drugs induced erection in a manner similar to that of intracorporeal injection of papaverine. Internal pudendal arterial flow increased slightly at the beginning of tumescence, and excellent venous restriction occurred. Intravenous injection, however, could neither induce an erection nor facilitate an erection after sub-threshold neurostimulation. We believe that the alpha-adrenergic antagonist properties of chlorpromazine and trazodone probably cause priapism by local action. © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByCOSTABILE R and SPEVAK M (2018) ORAL TRAZODONE IS NOT EFFECTIVE THERAPY FOR ERECTILE DYSFUNCTION: A DOUBLE-BLIND, PLACEBO CONTROLLED TRIALJournal of Urology, VOL. 161, NO. 6, (1819-1822), Online publication date: 1-Jun-1999.Steinberg J and Eyre R (2018) Management of Recurrent Priapism With Epinephrine Self-Injection and Gonadotropin-Releasing Hormone AnalogueJournal of Urology, VOL. 153, NO. 1, (152-153), Online publication date: 1-Jan-1995.Rosen S and Hanno P (2018) Clozapine-Induced PriapismJournal of Urology, VOL. 148, NO. 3 Part 1, (876-877), Online publication date: 1-Sep-1992.De Tejada I, Ware J, Blanco R, Pittard J, Nadig P, Azadzoi K, Krane R and Goldstein I (2018) Pathophysiology of Prolonged Penile Erection associated with Trazodone UseJournal of Urology, VOL. 145, NO. 1, (60-64), Online publication date: 1-Jan-1991.Azadzoi K, Payton T, Krane R and Goldstein I (2018) Effects of Intracavernosal Trazodone Hydrochloride: Animal and Human StudiesJournal of Urology, VOL. 144, NO. 5, (1277-1282), Online publication date: 1-Nov-1990.Lal S, Rios O and Thavundayil J (2018) Treatment of Impotence with Trazodone: A Case ReportJournal of Urology, VOL. 143, NO. 4, (819-820), Online publication date: 1-Apr-1990. Volume 137Issue 5May 1987Page: 1039-1042 Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Jason C. Abber More articles by this author Tom F. Lue More articles by this author Jian-An Luo More articles by this author Klaus-Peter Juenemann More articles by this author Emil A. Tanagho More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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• W8711136 title "Priapism Induced by Chlorpromazine and Trazodone: Mechanism of Action" @default.
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