Matches in SemOpenAlex for { <https://semopenalex.org/work/W871267826> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W871267826 abstract "The first aim of this study was to evaluate the extent of pathological changes in guinea pig liver following six weeks of dietary cholesterol (Chol) challenge. Livers from guinea pigs fed either low (L-Chol, 0.04%) or high (H-Chol, 0.25%) (n =10 per group) were examined for histological evidence of NAFLD and quantified for fatty acids (FA) in liver triglycerides (TG) and phospholipids (PL). H-Chol caused moderate hepatic steatosis and mild inflammation and coincided with marked depletion of total PUFA (p =0.03) and n6 PUFA content in PL (p =0.03), specifically arachidonic acid (p =0.001). A second aim was to investigate whether animals randomized to diets either low (LCD) (n =9) or high in carbohydrate (HCD) (n =10) following the H-Chol phase could improve liver pathology induced by H-Chol. Unexpectedly, despite less steatosis both groups displayed deterioration of liver pathology with evidence of hepatocyte ballooning, fibrosis, and biliary hyperplasia. Total PL PUFA (p =0.001) and n6 PUFA (p =0.001) were reduced compared to H-Chol and were inversely correlated with liver enzymes. Hepatic free cholesterol was increased in LCD and HCD livers with the most severe liver damage. These data identify a relationship between Chol-induced liver injury and PL composition; additionally, excess cholesterol has profound effects on hepatic morphology, which appears unresponsive to dietary intervention." @default.
- W871267826 created "2016-06-24" @default.
- W871267826 creator A5003751543 @default.
- W871267826 creator A5017102102 @default.
- W871267826 creator A5024250195 @default.
- W871267826 creator A5048345767 @default.
- W871267826 creator A5071325145 @default.
- W871267826 creator A5084170637 @default.
- W871267826 date "2013-04-01" @default.
- W871267826 modified "2023-09-26" @default.
- W871267826 title "Distinct pathological and lipidomic signature of guinea pigs with cholesterol‐induced non‐alcoholic fatty liver disease (NAFLD)" @default.
- W871267826 doi "https://doi.org/10.1096/fasebj.27.1_supplement.361.5" @default.
- W871267826 hasPublicationYear "2013" @default.
- W871267826 type Work @default.
- W871267826 sameAs 871267826 @default.
- W871267826 citedByCount "0" @default.
- W871267826 crossrefType "journal-article" @default.
- W871267826 hasAuthorship W871267826A5003751543 @default.
- W871267826 hasAuthorship W871267826A5017102102 @default.
- W871267826 hasAuthorship W871267826A5024250195 @default.
- W871267826 hasAuthorship W871267826A5048345767 @default.
- W871267826 hasAuthorship W871267826A5071325145 @default.
- W871267826 hasAuthorship W871267826A5084170637 @default.
- W871267826 hasConcept C126322002 @default.
- W871267826 hasConcept C134018914 @default.
- W871267826 hasConcept C181199279 @default.
- W871267826 hasConcept C19038510 @default.
- W871267826 hasConcept C2776175330 @default.
- W871267826 hasConcept C2776637226 @default.
- W871267826 hasConcept C2778078955 @default.
- W871267826 hasConcept C2778163477 @default.
- W871267826 hasConcept C2778772119 @default.
- W871267826 hasConcept C2779134260 @default.
- W871267826 hasConcept C2779478299 @default.
- W871267826 hasConcept C2780559512 @default.
- W871267826 hasConcept C543025807 @default.
- W871267826 hasConcept C55493867 @default.
- W871267826 hasConcept C71924100 @default.
- W871267826 hasConcept C86803240 @default.
- W871267826 hasConceptScore W871267826C126322002 @default.
- W871267826 hasConceptScore W871267826C134018914 @default.
- W871267826 hasConceptScore W871267826C181199279 @default.
- W871267826 hasConceptScore W871267826C19038510 @default.
- W871267826 hasConceptScore W871267826C2776175330 @default.
- W871267826 hasConceptScore W871267826C2776637226 @default.
- W871267826 hasConceptScore W871267826C2778078955 @default.
- W871267826 hasConceptScore W871267826C2778163477 @default.
- W871267826 hasConceptScore W871267826C2778772119 @default.
- W871267826 hasConceptScore W871267826C2779134260 @default.
- W871267826 hasConceptScore W871267826C2779478299 @default.
- W871267826 hasConceptScore W871267826C2780559512 @default.
- W871267826 hasConceptScore W871267826C543025807 @default.
- W871267826 hasConceptScore W871267826C55493867 @default.
- W871267826 hasConceptScore W871267826C71924100 @default.
- W871267826 hasConceptScore W871267826C86803240 @default.
- W871267826 hasIssue "S1" @default.
- W871267826 hasLocation W8712678261 @default.
- W871267826 hasOpenAccess W871267826 @default.
- W871267826 hasPrimaryLocation W8712678261 @default.
- W871267826 hasRelatedWork W1975489439 @default.
- W871267826 hasRelatedWork W2038159864 @default.
- W871267826 hasRelatedWork W2187035901 @default.
- W871267826 hasRelatedWork W2549327669 @default.
- W871267826 hasRelatedWork W2576488295 @default.
- W871267826 hasRelatedWork W2790198401 @default.
- W871267826 hasRelatedWork W2944404811 @default.
- W871267826 hasRelatedWork W3022652730 @default.
- W871267826 hasRelatedWork W3167481309 @default.
- W871267826 hasRelatedWork W4380201107 @default.
- W871267826 hasVolume "27" @default.
- W871267826 isParatext "false" @default.
- W871267826 isRetracted "false" @default.
- W871267826 magId "871267826" @default.
- W871267826 workType "article" @default.