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• W87155131 abstract "A szomatosztatin 2-es tipusu receptor (sst2) in vivo agonista-indukalt internalizacioja lehetőve tette a receptort expresszalo sejtek azonositasat a patkany parietalis agykergeben. Az sst2 receptor a kereg V. retegeben pyramissejteken, a VI. retegben kismeretű multipolaris, feltetelezhetően glutamaterg neuronokon helyezkedik el. Az sst2 receptor a gyrus dentatusban es a hypothalamus paraventricularis es arcuatus magjaiban perikaryonok es dendritek sejtmembranjan helyezkedik el, extraszinaptikusan, egyenletes eloszlasban. A receptor periszinaptikus vagy/es szinaptikus elhelyezkedeset vizsgalataink nem tamasztottak ala. Agonista hatasara a hippocampus pyramis- es szemcsesejtjeinek dendritjein elhelyezkedő sst2 receptorok retrograd uton, mikrotubulus-dependens transzporttal a sejttestbe vandorolnak, ott a transz-Golgi halozatban es a kozeleben elhelyezkedő vezikulakban tarolodnak, majd visszakerulnek a dendritek membranjara. Hippocampus sclerosissal jaro temporalis lebeny epilepsziaban a gyrus dentatus molekularis retegenek kulső reszeben, a szomatosztatinerg idegrostok hipertrofiajanak megfelelően a szomatosztatin sst2 receptoranak helyi down-regulacioja kovetkezik be. A down-regulacio feltehetően a kronikusan megnovekedett szomatosztatin felszabadulas kovetkezmenye. | Unraveling the distribution of somatostatin sst2 receptor in the rat parietal cortex was achieved through in vivo agonist-induced internalization of the receptor. Sst2 receptor-expressing cells are pyramidal cells in layer V and small multipolar, presumably glutamatergic neurons in layer VI. In the dentate gyrus and the hypothalamic paraventricular and arcuate nuclei, the sst2 receptor is localized at the plasma membrane of perikarya and dendrites. The sst2 receptor evenly distributed on the entire membrane surface, specific targeting of the receptor to perisynaptic and/or synaptic sites was not revealed. Upon agonist stimulation, dendritic receptors of hippocampal pyramidal and granule cells are retrogradely transported through a microtubule-dependent mechanism to a trans-Golgi network domain, before recycling. In temporal lobe epilepsy with hippocampal sclerosis, in the outer molecular layer of the dentate gyrus, the somatostatin sst2 receptor undergo local down-regulation which corresponded with the sprouting of somatostatinergic fibers. This receptor down-regulation is likely result from chronic somatostatin exposure." @default.
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• W87155131 title "Szomatosztatin receptor funkcionális morfológiai vizsgálata a központi idegrendszerben = Functional morphological study of somatostin receptors in the central nervous system" @default.
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