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- W872006010 abstract "目的分析北京家族结核分支杆菌,从分子流行病学角度探讨北京、广东及宁夏三地结核分支杆菌的分布特征.方法采用Gel compare 4.1软件对来自三地的206株结核分支杆菌的插入序列IS6110 DNA指纹图谱进行数字化,经互联网与世界结核分支杆菌DNA指纹库进行相似性比较;同时应用该软件对上述菌株行聚类分析;构建标准的结核分支杆菌Spoligotyping(间隔区寡核苷酸分型法)DNA指纹方法;用χ2检验比较不同组别肺结核病人临床分离菌株成簇率的差别,同时计算相对危险度(OR).结果 206株结核分支杆菌的IS6110 DNA指纹图谱与DNA指纹图谱库相比较,未发现相同者.56.8%(117/206)的结核分支杆菌IS6110 DNA指纹相似值在1.00～0.65之间,且它们的Spoligotyping指纹图谱均与北京家族结核分支杆菌相一致;分组统计显示:男性组与女性组、年龄≥42岁组与＜42岁组成簇率之间差异有显著性(P＜0.05),OR值为男性4.43,95%CI:0.94～28.76;＜42岁为5.06,95%CI:1.00～34.34.其他各组之间差异无显著统计学意义(P＞0.05).结论 北京家族结核分支杆菌在三地呈较高水平的流行;结核分支杆菌在男性和＜42岁人群中的传播频率较女性和≥42岁人群为高,且男性和＜42岁可能是三地结核病近期传播的危险因素.利用结核分支杆菌的DNA指纹图谱和互联网技术,可以实现结核分支杆菌传染源全球范围的追踪." @default.
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- W872006010 date "2003-01-01" @default.
- W872006010 modified "2023-09-23" @default.
- W872006010 title "北京、广东、宁夏三地结核分支杆菌DNA指纹的应用研究" @default.
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