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- W872043229 abstract "ABSTRACT This study aim to disclose a possible mechanism for the neuronal cell death induced by peripheral nerve injury followinga spinal nerve ligation (SNL) as a neuropathic pain model. Male Sprague-Dawley rats (270~290 g) were used for thisstudy. Pain threshold was evaluated for their response to mechanical(von Frey hairs) stimuli 1, 3, and 7 days after a tightligation of L5 ventral ramus. In control group, the small ganglion cells were strongly stained with routine toluidine blue(TB), whereas the large gang-lion cells showed a little bit weak stainity. Each large ganglion cell is surrounded by perineuronal satellite cells. In experimental groups, small ganglion cells showing apparent degenerative changes increased on 1day, and showed apeak in degenerative cell number at 3days group, and decreased gradually at 7days group. We also found a small numberof large-sized ganglion cells showing mild degenerative changes. However their satellite cells ware relatively intact withno typical findings throughout this experiment. Under the electron microscope, small ganglion cells showed various stageand typical features of the dark degeneration including mitochondrial swelling. Keywords : Dark degeneration, Ganglion cell, Nerve ligation, Rat" @default.
- W872043229 created "2016-06-24" @default.
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- W872043229 date "2009-01-01" @default.
- W872043229 modified "2023-09-23" @default.
- W872043229 title "Degenerative Changes of the Rat Dorsal Root Ganglion (DRG) Cells Following a Tight Spinal Nerve Ligation" @default.
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