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- W87328082 abstract "The CYP450 enzymes are the primary phase I enzymes responsible for metabolizing approximately 75% of drugs. Most of this metabolism is mediated by the xenobiotic-metabolizing hepatically expressed CYP450 isoforms CYP1A2, CYP2C8/9/19, CYP2D6, CYP2E1, and CYP3A4/5. Early researchers identified differences in CYP450-mediated metabolism among racial/ethnic groups. Identification of the genetic determinants of these differences spawned the field of pharmacogenetics. Today we continue to identify the genetic and environmental determinants of drug response variability on both individual and group levels. Although race is a social construct, racial stratification is often a necessity in population genetic studies involving CYP450 genes. However, the contribution of interethnic genetic variation is minimal compared to interindividual variation. Still, unstable genes linked to environmental circumstances such as CYP450 vary dramatically among different races and ethnicities. Many examples of racial/ethnic differences in CYP450 allele frequencies and haplotype blocks have been identified. Not surprisingly, variant metabolic phenotype prevalences, such as poor or rapid metabolizers, differ among racial/ethnic groups. The wealth of pharmacogenetic data accumulated thus far regarding CYP450 isoforms has led to many drug-labeling notices and/or dosing recommendations for individuals with variant metabolic phenotypes who may be taking specific drugs. As more data is gathered and as understanding of individual pharmacogenetic information such as metabolic phenotype becomes more widespread, personalized medicine becomes more a reality. Enhanced understanding of drug- and patient-specific pharmacogenetic data will allow prescribers to maximize drug efficacy for their patients while minimizing risks for toxicity and side effects." @default.
- W87328082 created "2016-06-24" @default.
- W87328082 creator A5079860808 @default.
- W87328082 date "2014-01-01" @default.
- W87328082 modified "2023-10-17" @default.
- W87328082 title "CYP450 and Ethnicity" @default.
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- W87328082 doi "https://doi.org/10.1016/b978-0-12-386882-4.00016-5" @default.
- W87328082 hasPublicationYear "2014" @default.
- W87328082 type Work @default.