Matches in SemOpenAlex for { <https://semopenalex.org/work/W873670620> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W873670620 abstract "The current study was designed to investigate the effects of 17ß-estradiol (E2) on cardiac remodeling. To address this issue, we evaluated cardiac fibrosis and hypertrophy in deoxycorticosterone acetate (DOCA)-salt treated rats with chronic, six-week administration of two different doses of E2. Female SD rats were ovariectomized bilaterally (Ovex). Hypertension was induced by subcutaneous implantation of DOCA-pellet in uninephrectomized animals, which were later maintained on 1% saline. The rats were randomly assigned to one of the following groups: Ovex control; Ovex + DOCA; Ovex + DOCA + E2 (low dose); or Ovex + DOCA + E2 (high dose). Blood pressure measurement showed a significant increase in DOCA treated rats over a six week period, which was not altered by estrogen replacement. No difference in cardiac function was observed among the different groups when assessed using isolated rat heart Langendorff apparatus. Both doses of estrogen attenuated cardiac hypertrophy observed in the DOCA treated animals. However, when measuring cardiac fibrosis induced by DOCA treatment, only the low dose E2 therapy showed a protective effect. The high dose E2 therapy failed to exhibit anti-fibrotic effects. These findings suggest that estrogen replacement therapy may have blood-pressure independent cardio-protective effects that are dose-dependent." @default.
- W873670620 created "2016-06-24" @default.
- W873670620 creator A5014426469 @default.
- W873670620 creator A5029335956 @default.
- W873670620 creator A5041313578 @default.
- W873670620 creator A5055424104 @default.
- W873670620 creator A5065721284 @default.
- W873670620 creator A5085916275 @default.
- W873670620 creator A5091617514 @default.
- W873670620 date "2009-04-01" @default.
- W873670620 modified "2023-10-16" @default.
- W873670620 title "Low dose but not high dose of 17â‐estradiol prevents cardiac fibrosis in DOCA‐salt model of hypertension in rats" @default.
- W873670620 doi "https://doi.org/10.1096/fasebj.23.1_supplement.lb77" @default.
- W873670620 hasPublicationYear "2009" @default.
- W873670620 type Work @default.
- W873670620 sameAs 873670620 @default.
- W873670620 citedByCount "0" @default.
- W873670620 crossrefType "journal-article" @default.
- W873670620 hasAuthorship W873670620A5014426469 @default.
- W873670620 hasAuthorship W873670620A5029335956 @default.
- W873670620 hasAuthorship W873670620A5041313578 @default.
- W873670620 hasAuthorship W873670620A5055424104 @default.
- W873670620 hasAuthorship W873670620A5065721284 @default.
- W873670620 hasAuthorship W873670620A5085916275 @default.
- W873670620 hasAuthorship W873670620A5091617514 @default.
- W873670620 hasConcept C111566952 @default.
- W873670620 hasConcept C126322002 @default.
- W873670620 hasConcept C134018914 @default.
- W873670620 hasConcept C2776002628 @default.
- W873670620 hasConcept C2777164284 @default.
- W873670620 hasConcept C2777420927 @default.
- W873670620 hasConcept C2778198053 @default.
- W873670620 hasConcept C2780559512 @default.
- W873670620 hasConcept C71924100 @default.
- W873670620 hasConcept C8264082 @default.
- W873670620 hasConcept C84393581 @default.
- W873670620 hasConceptScore W873670620C111566952 @default.
- W873670620 hasConceptScore W873670620C126322002 @default.
- W873670620 hasConceptScore W873670620C134018914 @default.
- W873670620 hasConceptScore W873670620C2776002628 @default.
- W873670620 hasConceptScore W873670620C2777164284 @default.
- W873670620 hasConceptScore W873670620C2777420927 @default.
- W873670620 hasConceptScore W873670620C2778198053 @default.
- W873670620 hasConceptScore W873670620C2780559512 @default.
- W873670620 hasConceptScore W873670620C71924100 @default.
- W873670620 hasConceptScore W873670620C8264082 @default.
- W873670620 hasConceptScore W873670620C84393581 @default.
- W873670620 hasIssue "S1" @default.
- W873670620 hasLocation W8736706201 @default.
- W873670620 hasOpenAccess W873670620 @default.
- W873670620 hasPrimaryLocation W8736706201 @default.
- W873670620 hasRelatedWork W1979733406 @default.
- W873670620 hasRelatedWork W2002384464 @default.
- W873670620 hasRelatedWork W2024405772 @default.
- W873670620 hasRelatedWork W2059229723 @default.
- W873670620 hasRelatedWork W2081992208 @default.
- W873670620 hasRelatedWork W2085668963 @default.
- W873670620 hasRelatedWork W2090136455 @default.
- W873670620 hasRelatedWork W2092722075 @default.
- W873670620 hasRelatedWork W2108578925 @default.
- W873670620 hasRelatedWork W2167902350 @default.
- W873670620 hasVolume "23" @default.
- W873670620 isParatext "false" @default.
- W873670620 isRetracted "false" @default.
- W873670620 magId "873670620" @default.
- W873670620 workType "article" @default.