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- W8738008 abstract "5-hydroxytryptamine (5-HT) caused concentration-dependent relaxation of isolated rings from porcine vena cava contracted with α-methyl 5-HT or prostaglandin F2α. Relaxation was not blocked by propranolol (1 μm), atropine (1 μm), indomethacin (3 μm), mepyramine (1 μm), cimetidine (1 μm), or cocaine (10 μm). Further receptor analysis could not be performed by antagonism of the relaxant response but was possible using 5-HT induced increases in cyclic AMP. Methysergide (1 μm) but not cyproheptadine (0.1 μm), specifically antagonised the 5-HT induced increase in cyclic AMP with an estimated pA2 of 7.19. The α-methyl analogue of 5-HT, a potent agonist at M and D receptors, did not cause relaxation or elevate cyclic AMP. These results suggest that the 5-HT receptor described here is not of the classical M or D type and unlike that described thus far in the vasculature. This receptor shares some similarities with brain 5-HT1 receptors since both may be linked with adenylate cyclase." @default.
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- W8738008 date "1984-07-01" @default.
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- W8738008 title "5-hydroxytryptamine-induced relaxation of neonatal porcine vena cava in vitro" @default.
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- W8738008 doi "https://doi.org/10.1016/0024-3205(84)90240-6" @default.
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