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- W874244402 abstract "p16^(INK4), which is a 16-kDa polypeptide protein, inhibits the catalytic activity of the CDK4-cyclinD complex to suppress tumor growth. Both unlabeled and isotope-labeled human tumor suppressor p16^(INK4) protein were overexpressed and purified to characterize biochemical and structural properties. The purified p16 binds to monomeric GST-CDK4 and exists in a monomer conformation for several weeks at 4℃. The circular dichroism (CD) data indicates that p16 contains high percentage of α-helix and that the helix percentage maximized at pH value of 7.0. One- and two-dimensional nuclear magnetic resonance (NMR) data suggest that purified p16 from our construct has a unique folded conformation under our experimental conditions and exhibits quite stable conformational characteristics." @default.
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- W874244402 date "1998-01-31" @default.
- W874244402 modified "2023-09-23" @default.
- W874244402 title "Articles : Overexpression and Spectroscopic Characterization of a Recombinant Human Tumor Suppressor p16INK4" @default.
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