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• W874961282 endingPage "e1005382" @default.
• W874961282 startingPage "e1005382" @default.
• W874961282 abstract "Fine-tuning the plasma-membrane permeability to essential nutrients is fundamental to cell growth optimization. Nutritional signals including nitrogen availability are integrated by the TORC1 complex which notably regulates arrestin-mediated endocytosis of amino-acid transporters. Ammonium is a ubiquitous compound playing key physiological roles in many, if not all, organisms. In yeast, it is a preferred nitrogen source transported by three Mep proteins which are orthologues of the mammalian Rhesus factors. By combining genetic, kinetic, biochemical and cell microscopy analyses, the current study reveals a novel mechanism enabling TORC1 to regulate the inherent activity of ammonium transport proteins, independently of arrestin-mediated endocytosis, identifying the still functional orphan Amu1/Par32 as a selective regulator intermediate. We show that, under poor nitrogen supply, the TORC1 effector kinase' Npr1' promotes phosphorylation of Amu1/Par32 which appears mainly cytosolic while ammonium transport proteins are active. Upon preferred nitrogen supplementation, like glutamine or ammonium addition, TORC1 upregulation enables Npr1 inhibition and Amu1/Par32 dephosphorylation. In these conditions, as in Npr1-lacking cells, hypophosphorylated Amu1/Par32 accumulates at the cell surface and mediates the inhibition of specific ammonium transport proteins. We show that the integrity of a conserved repeated motif of Amu1/Par32 is required for the interaction with these transport proteins. This study underscores the diversity of strategies enabling TORC1-Npr1 to selectively monitor cell permeability to nutrients by discriminating between transporters to be degraded or transiently inactivated and kept stable at the plasma membrane. This study further identifies the function of Amu1/Par32 in acute control of ammonium transport in response to variations in nitrogen availability." @default.
• W874961282 created "2016-06-24" @default.
• W874961282 creator A5008992952 @default.
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• W874961282 creator A5069377377 @default.
• W874961282 creator A5088413885 @default.
• W874961282 creator A5089468313 @default.
• W874961282 date "2015-07-14" @default.
• W874961282 modified "2023-10-18" @default.
• W874961282 title "Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32" @default.
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• W874961282 doi "https://doi.org/10.1371/journal.pgen.1005382" @default.
• W874961282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4501750" @default.
• W874961282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26172854" @default.
• W874961282 hasPublicationYear "2015" @default.
• W874961282 type Work @default.
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