Matches in SemOpenAlex for { <https://semopenalex.org/work/W875660514> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W875660514 abstract "Background: Mitral valve repair with ring annuloplasty for ischemic mitral regurgitation (IMR) is associated with significant recurrent IMR due to continued left ventricular (LV) remodeling as it does not directly address LV and mitral valve tethering. We aimed to assess chronic implantation of novel polymer based mesh device to reduce IMR reduction and reverse LV remodeling. Methods: Five Dorset sheep underwent ligation of second and third circumflex obtuse marginal branches to produce chronic IMR after 8 weeks. Poly-mesh was attached to the infarcted myocardium underlying the papillary muscle with a further 8 weeks follow-up. In addition, chronic IMR was produced in 5 untreated control sheep. IMR severity was assessed by 2D vena contracta width (VCW) and 3D vena contracta area (VCA). LV end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF) by 2D echo and hemodynamic data were also obtained at each baseline, chronic MR, and chronic poly-mesh stages. Results: In all sheep, after poly-mesh attachment, IMR decreased and this reduction persisted over 8 weeks (VCW 0.42±0.09 to 0.08±0.12cm; VCA 0.13±0.08 to 0.05±0.08cmsq, p<0.01) with significant increase in Emax (1.1±0.5 to 2.9±0.7mmHg/ml, p<0.05). There were no significant changes in LVEF (45.4±6.7 vs 42.6±3.5%, p=NS). Importantly, LV EDV and ESV at chronic poly-mesh stage were reduced compared to the chronic MR stage (EDV 110±15 to 88±18ml, p<0.05; ESV 61±14 to 51±12ml, p=NS) and % increases of both EDV and ESV from chronic MR to chronic poly-mesh stage were significantly lower than those of untreated control sheep (%EDV change -22±11 vs 11±10%, p<0.01; %ESV change -10±14 vs 9±10%, p<0.05) (FIGURE). Conclusions: Chronic follow up after polymer-mesh device attachment shows the stabilization of mitral-LV complex in a chronic IMR model, causing persistent reduction of IMR and preventing continued LV remodeling." @default.
- W875660514 created "2016-06-24" @default.
- W875660514 creator A5003717488 @default.
- W875660514 creator A5011095266 @default.
- W875660514 creator A5031005593 @default.
- W875660514 creator A5032239740 @default.
- W875660514 creator A5034311584 @default.
- W875660514 creator A5057136414 @default.
- W875660514 creator A5062710773 @default.
- W875660514 creator A5071417647 @default.
- W875660514 creator A5072003598 @default.
- W875660514 creator A5073107088 @default.
- W875660514 creator A5082020218 @default.
- W875660514 creator A5084294542 @default.
- W875660514 date "2014-11-25" @default.
- W875660514 modified "2023-09-23" @default.
- W875660514 title "Abstract 9480: Persistent MR Reduction With Stabilization of LV Remodeling and Following Chronic Polymer-Mesh Device on Infarcted Myocardium in a Chronic Ischemic MR Model" @default.
- W875660514 doi "https://doi.org/10.1161/circ.130.suppl_2.9480" @default.
- W875660514 hasPublicationYear "2014" @default.
- W875660514 type Work @default.
- W875660514 sameAs 875660514 @default.
- W875660514 citedByCount "0" @default.
- W875660514 crossrefType "journal-article" @default.
- W875660514 hasAuthorship W875660514A5003717488 @default.
- W875660514 hasAuthorship W875660514A5011095266 @default.
- W875660514 hasAuthorship W875660514A5031005593 @default.
- W875660514 hasAuthorship W875660514A5032239740 @default.
- W875660514 hasAuthorship W875660514A5034311584 @default.
- W875660514 hasAuthorship W875660514A5057136414 @default.
- W875660514 hasAuthorship W875660514A5062710773 @default.
- W875660514 hasAuthorship W875660514A5071417647 @default.
- W875660514 hasAuthorship W875660514A5072003598 @default.
- W875660514 hasAuthorship W875660514A5073107088 @default.
- W875660514 hasAuthorship W875660514A5082020218 @default.
- W875660514 hasAuthorship W875660514A5084294542 @default.
- W875660514 hasConcept C126322002 @default.
- W875660514 hasConcept C164705383 @default.
- W875660514 hasConcept C178853913 @default.
- W875660514 hasConcept C179437574 @default.
- W875660514 hasConcept C182536299 @default.
- W875660514 hasConcept C2777274916 @default.
- W875660514 hasConcept C2778198053 @default.
- W875660514 hasConcept C2779537366 @default.
- W875660514 hasConcept C2909944400 @default.
- W875660514 hasConcept C2993373945 @default.
- W875660514 hasConcept C71924100 @default.
- W875660514 hasConcept C78085059 @default.
- W875660514 hasConceptScore W875660514C126322002 @default.
- W875660514 hasConceptScore W875660514C164705383 @default.
- W875660514 hasConceptScore W875660514C178853913 @default.
- W875660514 hasConceptScore W875660514C179437574 @default.
- W875660514 hasConceptScore W875660514C182536299 @default.
- W875660514 hasConceptScore W875660514C2777274916 @default.
- W875660514 hasConceptScore W875660514C2778198053 @default.
- W875660514 hasConceptScore W875660514C2779537366 @default.
- W875660514 hasConceptScore W875660514C2909944400 @default.
- W875660514 hasConceptScore W875660514C2993373945 @default.
- W875660514 hasConceptScore W875660514C71924100 @default.
- W875660514 hasConceptScore W875660514C78085059 @default.
- W875660514 hasIssue "suppl_2" @default.
- W875660514 hasLocation W8756605141 @default.
- W875660514 hasOpenAccess W875660514 @default.
- W875660514 hasPrimaryLocation W8756605141 @default.
- W875660514 hasRelatedWork W13584046 @default.
- W875660514 hasRelatedWork W190929261 @default.
- W875660514 hasRelatedWork W1997470369 @default.
- W875660514 hasRelatedWork W2013964042 @default.
- W875660514 hasRelatedWork W2022340155 @default.
- W875660514 hasRelatedWork W2050144986 @default.
- W875660514 hasRelatedWork W2069811865 @default.
- W875660514 hasRelatedWork W2073054236 @default.
- W875660514 hasRelatedWork W2092285554 @default.
- W875660514 hasRelatedWork W2127230228 @default.
- W875660514 hasRelatedWork W2323305052 @default.
- W875660514 hasRelatedWork W2395099378 @default.
- W875660514 hasRelatedWork W2472189811 @default.
- W875660514 hasRelatedWork W2768184499 @default.
- W875660514 hasRelatedWork W2772422356 @default.
- W875660514 hasRelatedWork W2796304141 @default.
- W875660514 hasRelatedWork W2903067100 @default.
- W875660514 hasRelatedWork W2969688984 @default.
- W875660514 hasRelatedWork W3082541159 @default.
- W875660514 hasRelatedWork W3092217935 @default.
- W875660514 hasVolume "130" @default.
- W875660514 isParatext "false" @default.
- W875660514 isRetracted "false" @default.
- W875660514 magId "875660514" @default.
- W875660514 workType "article" @default.