FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W87609575> ?p ?o ?g. }

• W87609575 endingPage "237" @default.
• W87609575 startingPage "215" @default.
• W87609575 abstract "The cation chloride cotransporters (CCCs) represent an important family of transporters that plays key roles in vectorial electrolyte movement across epithelia and in intracellular chloride homeostasis of neurons and muscle cells. The CCCs are composed of three broad groups, two of which include multiple isoforms: Na-Cl cotransporter (NCC; SLC12A3), Na-K-2Cl cotransporter (NKCC; SLC12A1-2), and K-Cl cotransporter (KCC; SLC12A4-7). The CCCs are inhibited by clinically relevant drugs, including loop diuretics that inhibit NKCC2 in the renal thick ascending limb and thiazide diuretics that inhibit NCC in the renal distal tubule. For many years, much research on this gene family has centered on understanding ion binding and inhibitor interaction which represent important features of the molecular operation of these transporters. Recently, high resolution structures of bacterial transport proteins related to the CCCs have become available, thus permitting structural context in which to evaluate previous ion and inhibitor studies of the CCCs. In this article, I review past molecular and structure-function studies that have provided key pieces of information about ion binding and inhibitor interaction primarily of NKCC for which we have the most information. I then place these findings into the structural context of recent homology models of NKCC based on the outward-facing open and occluded conformations of the related bacterial transporters. These homology models provide our first glimpse into the fine details of the molecular operation of the CCCs." @default.
• W87609575 created "2016-06-24" @default.
• W87609575 creator A5050619139 @default.
• W87609575 date "2012-01-01" @default.
• W87609575 modified "2023-10-18" @default.
• W87609575 title "Molecular Operation of the Cation Chloride Cotransporters" @default.
• W87609575 cites W1496152617 @default.
• W87609575 cites W1552509407 @default.
• W87609575 cites W1580090335 @default.
• W87609575 cites W1584363878 @default.
• W87609575 cites W1588629441 @default.
• W87609575 cites W1663064741 @default.
• W87609575 cites W1930193918 @default.
• W87609575 cites W196265265 @default.
• W87609575 cites W1967348685 @default.
• W87609575 cites W1975518622 @default.
• W87609575 cites W1982088748 @default.
• W87609575 cites W1985793100 @default.
• W87609575 cites W1990690213 @default.
• W87609575 cites W1991558412 @default.
• W87609575 cites W1993652234 @default.
• W87609575 cites W1995994950 @default.
• W87609575 cites W1997674502 @default.
• W87609575 cites W1998077260 @default.
• W87609575 cites W1998624358 @default.
• W87609575 cites W2004995590 @default.
• W87609575 cites W2006819060 @default.
• W87609575 cites W2011757599 @default.
• W87609575 cites W2013908828 @default.
• W87609575 cites W2015066227 @default.
• W87609575 cites W2017791457 @default.
• W87609575 cites W2017948089 @default.
• W87609575 cites W2019909157 @default.
• W87609575 cites W2020731816 @default.
• W87609575 cites W2021564100 @default.
• W87609575 cites W2033979463 @default.
• W87609575 cites W2035833733 @default.
• W87609575 cites W2042015732 @default.
• W87609575 cites W2042766259 @default.
• W87609575 cites W2043815378 @default.
• W87609575 cites W2044313153 @default.
• W87609575 cites W2047872096 @default.
• W87609575 cites W2049519918 @default.
• W87609575 cites W2049824487 @default.
• W87609575 cites W2051231609 @default.
• W87609575 cites W2057119505 @default.
• W87609575 cites W2062146437 @default.
• W87609575 cites W2063829366 @default.
• W87609575 cites W2064946020 @default.
• W87609575 cites W2073047945 @default.
• W87609575 cites W2074274532 @default.
• W87609575 cites W2076795031 @default.
• W87609575 cites W2082667125 @default.
• W87609575 cites W2090362914 @default.
• W87609575 cites W2092398899 @default.
• W87609575 cites W2093172752 @default.
• W87609575 cites W2095267065 @default.
• W87609575 cites W2104622728 @default.
• W87609575 cites W2108161822 @default.
• W87609575 cites W2113336835 @default.
• W87609575 cites W2115430354 @default.
• W87609575 cites W2130493951 @default.
• W87609575 cites W2134263027 @default.
• W87609575 cites W2156212384 @default.
• W87609575 cites W2164797647 @default.
• W87609575 cites W2404294586 @default.
• W87609575 cites W2418510852 @default.
• W87609575 cites W2420946172 @default.
• W87609575 cites W90751401 @default.
• W87609575 doi "https://doi.org/10.1016/b978-0-12-394316-3.00006-5" @default.
• W87609575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23177987" @default.
• W87609575 hasPublicationYear "2012" @default.
• W87609575 type Work @default.
• W87609575 sameAs 87609575 @default.
• W87609575 citedByCount "34" @default.
• W87609575 countsByYear W876095752013 @default.
• W87609575 countsByYear W876095752014 @default.
• W87609575 countsByYear W876095752015 @default.
• W87609575 countsByYear W876095752017 @default.
• W87609575 countsByYear W876095752018 @default.
• W87609575 countsByYear W876095752019 @default.
• W87609575 countsByYear W876095752020 @default.
• W87609575 countsByYear W876095752021 @default.
• W87609575 countsByYear W876095752022 @default.
• W87609575 countsByYear W876095752023 @default.
• W87609575 crossrefType "book-chapter" @default.
• W87609575 hasAuthorship W87609575A5050619139 @default.
• W87609575 hasConcept C104317684 @default.
• W87609575 hasConcept C120405084 @default.
• W87609575 hasConcept C12554922 @default.
• W87609575 hasConcept C134018914 @default.
• W87609575 hasConcept C149011108 @default.
• W87609575 hasConcept C151730666 @default.
• W87609575 hasConcept C159641895 @default.
• W87609575 hasConcept C168785527 @default.
• W87609575 hasConcept C169627665 @default.
• W87609575 hasConcept C178790620 @default.
• W87609575 hasConcept C181199279 @default.

• next