Matches in SemOpenAlex for { <https://semopenalex.org/work/W87621787> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W87621787 abstract "A defining characteristic of the ill-defined disorder MCS is an avoidance of odors. Another symptom, anxiety, has led some investigators to draw parallels between MCS and other disorders such as panic and posttraumatic stress. Panic disorder can be modeled in animals by fear conditioning; therefore, we fear-conditioned animals to an odor (CS) paired with a 0.2mA footshock (US) and then tested for freezing and odor avoidance (fear responses). The underlying brain circuitry involved in these fear responses was tested via microinjection of the GABA agonists baclofen/muscimol (B/M) into either the basolateral amygdala (BLA), the central nucleus of the amygdala (CEA), or the medial prefrontal cortex (mPFC). Five minutes after drug infusion, rats were monitored for freezing behavior followed immediately by odor avoidance testing. Percent time freezing was lower in B/M-treated rats and higher in the BLA and CEA. Odor avoidance was lower in CEA B/M-treated rats versus controls and lower in mPFC B/M-treated rats versus controls. Our results indicate the involvement of the CEA in odor avoidance and the involvement of the mPFC in the extinction of odor avoidance. Supported by NIH grant ES-009135" @default.
- W87621787 created "2016-06-24" @default.
- W87621787 creator A5015469925 @default.
- W87621787 creator A5072554059 @default.
- W87621787 creator A5075471305 @default.
- W87621787 date "2007-01-01" @default.
- W87621787 modified "2023-09-23" @default.
- W87621787 title "Neural circuitry involved in fear conditioning and odor avoidance in an animal model for Multiple Chemical Sensitivity (MCS)" @default.
- W87621787 doi "https://doi.org/10.1096/fasebj.21.6.a788" @default.
- W87621787 hasPublicationYear "2007" @default.
- W87621787 type Work @default.
- W87621787 sameAs 87621787 @default.
- W87621787 citedByCount "0" @default.
- W87621787 crossrefType "journal-article" @default.
- W87621787 hasAuthorship W87621787A5015469925 @default.
- W87621787 hasAuthorship W87621787A5072554059 @default.
- W87621787 hasAuthorship W87621787A5075471305 @default.
- W87621787 hasConcept C101991246 @default.
- W87621787 hasConcept C118552586 @default.
- W87621787 hasConcept C126322002 @default.
- W87621787 hasConcept C15744967 @default.
- W87621787 hasConcept C16837860 @default.
- W87621787 hasConcept C169760540 @default.
- W87621787 hasConcept C169900460 @default.
- W87621787 hasConcept C170493617 @default.
- W87621787 hasConcept C185592680 @default.
- W87621787 hasConcept C199289684 @default.
- W87621787 hasConcept C2777529043 @default.
- W87621787 hasConcept C2778916471 @default.
- W87621787 hasConcept C2778938600 @default.
- W87621787 hasConcept C2779144063 @default.
- W87621787 hasConcept C2779188335 @default.
- W87621787 hasConcept C2780451725 @default.
- W87621787 hasConcept C2781069985 @default.
- W87621787 hasConcept C2781195155 @default.
- W87621787 hasConcept C558461103 @default.
- W87621787 hasConcept C71924100 @default.
- W87621787 hasConceptScore W87621787C101991246 @default.
- W87621787 hasConceptScore W87621787C118552586 @default.
- W87621787 hasConceptScore W87621787C126322002 @default.
- W87621787 hasConceptScore W87621787C15744967 @default.
- W87621787 hasConceptScore W87621787C16837860 @default.
- W87621787 hasConceptScore W87621787C169760540 @default.
- W87621787 hasConceptScore W87621787C169900460 @default.
- W87621787 hasConceptScore W87621787C170493617 @default.
- W87621787 hasConceptScore W87621787C185592680 @default.
- W87621787 hasConceptScore W87621787C199289684 @default.
- W87621787 hasConceptScore W87621787C2777529043 @default.
- W87621787 hasConceptScore W87621787C2778916471 @default.
- W87621787 hasConceptScore W87621787C2778938600 @default.
- W87621787 hasConceptScore W87621787C2779144063 @default.
- W87621787 hasConceptScore W87621787C2779188335 @default.
- W87621787 hasConceptScore W87621787C2780451725 @default.
- W87621787 hasConceptScore W87621787C2781069985 @default.
- W87621787 hasConceptScore W87621787C2781195155 @default.
- W87621787 hasConceptScore W87621787C558461103 @default.
- W87621787 hasConceptScore W87621787C71924100 @default.
- W87621787 hasFunder F4320332161 @default.
- W87621787 hasIssue "6" @default.
- W87621787 hasLocation W876217871 @default.
- W87621787 hasOpenAccess W87621787 @default.
- W87621787 hasPrimaryLocation W876217871 @default.
- W87621787 hasRelatedWork W1573440693 @default.
- W87621787 hasRelatedWork W1991182470 @default.
- W87621787 hasRelatedWork W1992402923 @default.
- W87621787 hasRelatedWork W2108888119 @default.
- W87621787 hasRelatedWork W2157398019 @default.
- W87621787 hasRelatedWork W2744667073 @default.
- W87621787 hasRelatedWork W2761259115 @default.
- W87621787 hasRelatedWork W2952322062 @default.
- W87621787 hasRelatedWork W2989479224 @default.
- W87621787 hasRelatedWork W2556876443 @default.
- W87621787 hasVolume "21" @default.
- W87621787 isParatext "false" @default.
- W87621787 isRetracted "false" @default.
- W87621787 magId "87621787" @default.
- W87621787 workType "article" @default.