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- W876291374 abstract "This chapter critically evaluates some common assumptions regarding antifungal resistance and highlights key clinical problems that arise when managing patients with invasive infections caused by antifungal-resistant Candida species. Although this paper gives perhaps the first example of in vivo-acquired mutations in a fungal gene with a positive impact on in vivo fitness, all of the clinical isolates used in the study were acquired from semi-invasive infections of the oropharynx rather than the bloodstream of patients. The majority of patients with invasive mycoses probably fail therapy because of underlying host factors, rather than acquired resistance to the drug. One of the most underappreciated causes of treatment failures in Candida species is biofilm-mediated resistance. Problems associated with timely diagnosis and early detection of antifungal resistance in Candida species have not improved over the last two decades, as current testing approaches still rely primarily on blood cultures, which may be negative for up to 50% of patients. It is critical that the diagnostics and treatment tools to manage antifungal resistance in Candida species be developed now, along with clinical stewardship programs to effectively integrate their use in clinic, so that we are better equipped to deal with the challenges on the horizon that will be encountered in an increasingly complex and aged population of patients in the health care system." @default.
- W876291374 created "2016-06-24" @default.
- W876291374 creator A5041039527 @default.
- W876291374 creator A5066067579 @default.
- W876291374 date "2014-04-09" @default.
- W876291374 modified "2023-09-27" @default.
- W876291374 title "The Impact of Antifungal Drug Resistance in the Clinic" @default.
- W876291374 cites W1595367033 @default.
- W876291374 cites W1653248413 @default.
- W876291374 cites W1756280447 @default.
- W876291374 cites W1821231206 @default.
- W876291374 cites W1823566177 @default.
- W876291374 cites W1966690773 @default.
- W876291374 cites W1974848894 @default.
- W876291374 cites W1978602955 @default.
- W876291374 cites W1979497376 @default.
- W876291374 cites W1979749196 @default.
- W876291374 cites W1985706241 @default.
- W876291374 cites W1986506708 @default.
- W876291374 cites W1987925654 @default.
- W876291374 cites W1990066520 @default.
- W876291374 cites W1992918524 @default.
- W876291374 cites W1999751604 @default.
- W876291374 cites W2002614555 @default.
- W876291374 cites W2003045858 @default.
- W876291374 cites W2005936443 @default.
- W876291374 cites W2007145765 @default.
- W876291374 cites W2014904057 @default.
- W876291374 cites W2019847904 @default.
- W876291374 cites W2027821217 @default.
- W876291374 cites W2029953856 @default.
- W876291374 cites W2030456354 @default.
- W876291374 cites W2032321007 @default.
- W876291374 cites W2032893561 @default.
- W876291374 cites W2033083353 @default.
- W876291374 cites W2033288552 @default.
- W876291374 cites W2034519764 @default.
- W876291374 cites W2034661822 @default.
- W876291374 cites W2035923800 @default.
- W876291374 cites W2045096565 @default.
- W876291374 cites W2047682827 @default.
- W876291374 cites W2051558930 @default.
- W876291374 cites W2052031328 @default.
- W876291374 cites W2054459659 @default.
- W876291374 cites W2061823928 @default.
- W876291374 cites W2062024095 @default.
- W876291374 cites W2062608319 @default.
- W876291374 cites W2064476714 @default.
- W876291374 cites W2064487923 @default.
- W876291374 cites W2066815221 @default.
- W876291374 cites W2067352964 @default.
- W876291374 cites W2072083697 @default.
- W876291374 cites W2077088073 @default.
- W876291374 cites W2084643045 @default.
- W876291374 cites W2087245820 @default.
- W876291374 cites W2087561016 @default.
- W876291374 cites W2087712604 @default.
- W876291374 cites W2089115810 @default.
- W876291374 cites W2092667553 @default.
- W876291374 cites W2093767199 @default.
- W876291374 cites W2095696028 @default.
- W876291374 cites W2097231068 @default.
- W876291374 cites W2097394217 @default.
- W876291374 cites W2098169836 @default.
- W876291374 cites W2098714617 @default.
- W876291374 cites W2098972478 @default.
- W876291374 cites W2099198339 @default.
- W876291374 cites W2099230922 @default.
- W876291374 cites W2099241550 @default.
- W876291374 cites W2099536314 @default.
- W876291374 cites W2100967944 @default.
- W876291374 cites W2101807890 @default.
- W876291374 cites W2102541629 @default.
- W876291374 cites W2105891919 @default.
- W876291374 cites W2106443705 @default.
- W876291374 cites W2106621186 @default.
- W876291374 cites W2108249211 @default.
- W876291374 cites W2108627308 @default.
- W876291374 cites W2112272778 @default.
- W876291374 cites W2114943619 @default.
- W876291374 cites W2115831228 @default.
- W876291374 cites W2117166221 @default.
- W876291374 cites W2118236446 @default.
- W876291374 cites W2118489318 @default.
- W876291374 cites W2119282845 @default.
- W876291374 cites W2120834638 @default.
- W876291374 cites W2121025359 @default.
- W876291374 cites W2122716163 @default.
- W876291374 cites W2126536749 @default.
- W876291374 cites W2129515144 @default.
- W876291374 cites W2131443556 @default.
- W876291374 cites W2131727615 @default.
- W876291374 cites W2131821856 @default.
- W876291374 cites W2133189384 @default.
- W876291374 cites W2135182325 @default.
- W876291374 cites W2135303569 @default.
- W876291374 cites W2135486637 @default.
- W876291374 cites W2137311774 @default.