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- W876663702 abstract "EGF receptor (EGFR), the VEGF and its receptors represent currently the most promising therapeutic targets in colorectal cancer. Strategies of EGFR targeting have been numerous with mainly monoclonal antibodies specifically binding the extracellular domain of the EGFR and enzymatic inhibitors of the intracellular part of the receptors with tyrosine kinase activity. These two latter therapeutic tools have been under active clinical development. The clinical application currently the most successful is the association of the anti-EGFR monoclonal antibody cetuximab with irinotecan in metastatic colorectal cancer. The therapeutic classes used to antagonize the EGFR were applied as well for VEGF targeting. Encouraging clinical results came from the association between an anti-VEGF antibody, bevacizumab with 5FU-folinic acid combination with or without irinotecan. Optimal associations are still awaited between targeted drugs and chemotherapy and between targeted drugs themselves. Reliable predictive tools are still needed to apply these treatments for potentially sensitive tumors only." @default.
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- W876663702 date "2006-01-01" @default.
- W876663702 modified "2023-09-24" @default.
- W876663702 title "Targeted therapy for colorectal cancer" @default.
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