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- W8766861 endingPage "718" @default.
- W8766861 startingPage "675" @default.
- W8766861 abstract "The study of drug transporter proteins has become both a critical and early investment in the drug discovery paradigm to address the potential for altered drug disposition. The anticipated human exposure level of a drug, as well as the therapeutic window of safety, should be compared to in vitro kinetic parameters of the drug to help determine the potential relevance of transporter interactions in clinical studies. The data obtained from in vitro assays can be applied to preclinical in vivo findings in the interpretation and prediction of human interactions, allowing refinement of clinical study design to address the transporter problems. It is common that more than one transporter protein is involved in the transport of a new molecular entity (NME). The multiplicity of transporter involvement makes it challenging to extrapolate the role of an individual protein in the overall disposition of the NME. Species differences in transporter-regulated tissue distribution and substrate specificity should be taken into account when extrapolating results obtained from preclinical species to humans. The advantages and limitations must always be applied to each preclinical tool. A transporter evaluation strategy may involve multiple steps and the use of different systems to integrate the information generated for predicting drug disposition in humans." @default.
- W8766861 created "2016-06-24" @default.
- W8766861 creator A5058112913 @default.
- W8766861 date "2013-01-01" @default.
- W8766861 modified "2023-10-14" @default.
- W8766861 title "Transporter study methodologies" @default.
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