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- W87686549 abstract "Tetracycline metabolites forming on the antibiotic exposure to visible light or peroxidase as well as tetracycline as such showed the ability to bind iron cations. When the metabolites bound the cations of iron protoxide, they catalyzed its oxidation. Chelating agents such as o-phenanthroline and EDTA arrested the ions of iron protoxide and iron oxide in the respective iron/tetracycline complexes at a much lower rate than that with the use of the native tetracycline. This means that the affinity of the metabolites with the above mentioned iron ions was much higher than that of the native tetracycline. When the metabolites and tetracycline bound iron protoxide, they catalyzed its oxidation to the oxide. Tetracycline and its metabolites were shown as well to have the property of reversible regeneration of iron oxide to the protoxide." @default.
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- W87686549 date "1995-10-01" @default.
- W87686549 modified "2023-09-23" @default.
- W87686549 title "[Chelating and oxidizing properties of tetracycline metabolites forming during its peroxidase or photoinduced oxidation]." @default.
- W87686549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8660122" @default.
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