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• W87794110 abstract "Epidemiological and animal studies have revealed that fetal exposure to malnutrition or overnutrition is associated with the development of type 2 diabetes and other features of the metabolic syndrome. The fetus is able to respond and adapt to suboptimal nutrition and other environmental cues but by doing so it permanently changes the structure, function, and metabolism of its body. Animal models have been established, to elucidate the mechanisms underlying the relationship between an early suboptimal environment and increased susceptibility to diseases in later life. Lipotoxicity, mitochondrial dysfunction, and increased oxidative stress, as well as epigenetic alterations, may also play important roles." @default.
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• W87794110 date "2013-01-01" @default.
• W87794110 modified "2023-09-23" @default.
• W87794110 title "Early origins of disease: Fetal" @default.
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• W87794110 doi "https://doi.org/10.1016/b978-0-12-375083-9.00081-7" @default.
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