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- W87817126 abstract "Abstract The role of microRNAs in CD8+ T cells responses is largely unexplored. We have found that miR-155 is upregulated by 100-fold in activated CD8+ T cells. To test the in vivo role of miR-155 in CD8+ T cell responses, we examined bic/miR-155 deficient (bic-/-) CD8+ T cells in Influenza type A virus or Listeria monocytogenes (L.m.) infected mice. To demonstrate that miR-155 deficiency induces an intrinsic defect in CD8+ T cells, bic-/-OT-1+ and OT-1+ transgenic CD8+ T cells were adoptively transferred into C57BL/6 hosts, and then either infected with SIINFEKL peptide expressing influenza virus strain WSN-OVA or recombinant L.m. strain expressing OVA (L.m.-OVA). At day 10 post-infection the number of pulmonary bic-/-OT-1+ CD8+ T cells was reduced 3-fold compared to OT-1+ CD8+ T cells (p=0.01). With L.m.-OVA infection, day 7 post-infection numbers of splenic bic-/-OT-1+ CD8+ T cells were 10-fold lower than OT-1+ CD8+ T cells (p=0.0005). On day 3 post-infection however, no differences were found between OT-1+ or bic-/-OT-1+ CD8+ T cells transferred animals and both groups equally controlled the bacterial burden in the spleen compared to non-transferred control animals suggesting that bic-/-OT-1+ CD8+ T cells transfer normally and that miR-155 regulates CD8+ T cell responses at the later stages of infection. These findings demonstrate that miR-155 plays a critical role in CD8+ T cell responses against pathogens." @default.
- W87817126 created "2016-06-24" @default.
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- W87817126 date "2009-04-01" @default.
- W87817126 modified "2023-09-26" @default.
- W87817126 title "A critical role for microRNA miR-155 in CD8+ T cell responses (90.23)" @default.
- W87817126 doi "https://doi.org/10.4049/jimmunol.182.supp.90.23" @default.
- W87817126 hasPublicationYear "2009" @default.
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