Matches in SemOpenAlex for { <https://semopenalex.org/work/W878990122> ?p ?o ?g. }
- W878990122 endingPage "11" @default.
- W878990122 startingPage "1" @default.
- W878990122 abstract "For the past decade, cardiac safety screening to evaluate the propensity of drugs to produce QT interval prolongation and Torsades de Pointes (TdP) arrhythmia has been conducted according to ICH S7B and ICH E14 guidelines. Central to the existing approach are hERG channel assays and in vivo QT measurements. Although effective, the present paradigm carries a risk of unnecessary compound attrition and high cost, especially when considering costly thorough QT (TQT) studies conducted later in drug development. The C: omprehensive I: n Vitro P: roarrhythmia A: ssay (CiPA) initiative is a public-private collaboration with the aim of updating the existing cardiac safety testing paradigm to better evaluate arrhythmia risk and remove the need for TQT studies. It is hoped that CiPA will produce a standardized ion channel assay approach, incorporating defined tests against major cardiac ion channels, the results of which then inform evaluation of proarrhythmic actions in silico, using human ventricular action potential reconstructions. Results are then to be confirmed using human (stem cell-derived) cardiomyocytes. This perspective article reviews the rationale, progress of, and challenges for the CiPA initiative, if this new paradigm is to replace existing practice and, in time, lead to improved and widely accepted cardiac safety testing guidelines." @default.
- W878990122 created "2016-06-24" @default.
- W878990122 creator A5001720031 @default.
- W878990122 creator A5016642736 @default.
- W878990122 creator A5020305696 @default.
- W878990122 creator A5021526672 @default.
- W878990122 creator A5031529358 @default.
- W878990122 creator A5033913734 @default.
- W878990122 creator A5035088716 @default.
- W878990122 creator A5035283852 @default.
- W878990122 creator A5035538956 @default.
- W878990122 creator A5037737415 @default.
- W878990122 creator A5039396759 @default.
- W878990122 creator A5039852503 @default.
- W878990122 creator A5045901294 @default.
- W878990122 creator A5051133526 @default.
- W878990122 creator A5063309069 @default.
- W878990122 creator A5067802232 @default.
- W878990122 creator A5070362977 @default.
- W878990122 creator A5071250391 @default.
- W878990122 creator A5072962782 @default.
- W878990122 creator A5075580993 @default.
- W878990122 creator A5078905944 @default.
- W878990122 creator A5084104321 @default.
- W878990122 date "2016-01-01" @default.
- W878990122 modified "2023-10-10" @default.
- W878990122 title "A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm" @default.
- W878990122 cites W1491280455 @default.
- W878990122 cites W1640055584 @default.
- W878990122 cites W1964284576 @default.
- W878990122 cites W1965682333 @default.
- W878990122 cites W1968856255 @default.
- W878990122 cites W1970250060 @default.
- W878990122 cites W1975438579 @default.
- W878990122 cites W1979417953 @default.
- W878990122 cites W1979950725 @default.
- W878990122 cites W1981644786 @default.
- W878990122 cites W1995849691 @default.
- W878990122 cites W1999254876 @default.
- W878990122 cites W2006214313 @default.
- W878990122 cites W2009177696 @default.
- W878990122 cites W2012930217 @default.
- W878990122 cites W2013430991 @default.
- W878990122 cites W2016157842 @default.
- W878990122 cites W2019973925 @default.
- W878990122 cites W2021775591 @default.
- W878990122 cites W2033765226 @default.
- W878990122 cites W2036038468 @default.
- W878990122 cites W2043913975 @default.
- W878990122 cites W2052017927 @default.
- W878990122 cites W2058204042 @default.
- W878990122 cites W2071420879 @default.
- W878990122 cites W2073921281 @default.
- W878990122 cites W2074527519 @default.
- W878990122 cites W2082135380 @default.
- W878990122 cites W2086869213 @default.
- W878990122 cites W2093638125 @default.
- W878990122 cites W2111061591 @default.
- W878990122 cites W2112360480 @default.
- W878990122 cites W2113927644 @default.
- W878990122 cites W2115765852 @default.
- W878990122 cites W2116581628 @default.
- W878990122 cites W2124929662 @default.
- W878990122 cites W2125055973 @default.
- W878990122 cites W2125199827 @default.
- W878990122 cites W2125570605 @default.
- W878990122 cites W2134935439 @default.
- W878990122 cites W2137618884 @default.
- W878990122 cites W2150629896 @default.
- W878990122 cites W2317440492 @default.
- W878990122 cites W4240747920 @default.
- W878990122 cites W4253853981 @default.
- W878990122 doi "https://doi.org/10.1177/1087057115594589" @default.
- W878990122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26170255" @default.
- W878990122 hasPublicationYear "2016" @default.
- W878990122 type Work @default.
- W878990122 sameAs 878990122 @default.
- W878990122 citedByCount "238" @default.
- W878990122 countsByYear W8789901222015 @default.
- W878990122 countsByYear W8789901222016 @default.
- W878990122 countsByYear W8789901222017 @default.
- W878990122 countsByYear W8789901222018 @default.
- W878990122 countsByYear W8789901222019 @default.
- W878990122 countsByYear W8789901222020 @default.
- W878990122 countsByYear W8789901222021 @default.
- W878990122 countsByYear W8789901222022 @default.
- W878990122 countsByYear W8789901222023 @default.
- W878990122 crossrefType "journal-article" @default.
- W878990122 hasAuthorship W878990122A5001720031 @default.
- W878990122 hasAuthorship W878990122A5016642736 @default.
- W878990122 hasAuthorship W878990122A5020305696 @default.
- W878990122 hasAuthorship W878990122A5021526672 @default.
- W878990122 hasAuthorship W878990122A5031529358 @default.
- W878990122 hasAuthorship W878990122A5033913734 @default.
- W878990122 hasAuthorship W878990122A5035088716 @default.
- W878990122 hasAuthorship W878990122A5035283852 @default.
- W878990122 hasAuthorship W878990122A5035538956 @default.
- W878990122 hasAuthorship W878990122A5037737415 @default.