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- W8791024 abstract "In 1976 Bonadonna and colleagues (1) revolutionized the treatment of breast cancer when they reported the positive effect of adjuvant cytototoxic chemotherapy in women with node-positive breast cancer. Women with node-positive breast malignancies who had undergone mastectomy with axillary dissection were randomized to observation or 12 cycles of chemotherapy with cyclophosphamide (C), methotrexate (M) and 5-fluorouracil (F). The initial analysis indicated that 24% of the patients in the observation cohort experienced treatment failure, whereas only 5.3% of the patients in the chemotherapy cohort developed disease recurrence. Besides hair loss and amenorrhea, the most common toxicities were thrombocytopenia (platelet count < 130 × 109/L) in 71% and leukopenia (white blood cell count < 4 × 109/L) in 71%. Patients in the treatment group had no increased rate of infection. The authors concluded that cytotoxic chemotherapy could be delivered safely with manageable toxicity and that it appeared to have an early impact on disease recurrence (1)." @default.
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- W8791024 date "2004-01-01" @default.
- W8791024 modified "2023-10-05" @default.
- W8791024 title "Use of Granulocyte Growth Factors in Breast Cancer" @default.
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- W8791024 doi "https://doi.org/10.1007/978-1-59259-747-5_15" @default.
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