Matches in SemOpenAlex for { <https://semopenalex.org/work/W879561210> ?p ?o ?g. }
- W879561210 abstract "Transcription factors of the fork head gene family play an important role during embryogenesis. The importance of this gene family shows up also in the fact that mutations in different human fork head genes lead to hereditary disorders. In this paper the homologous fork head genes of mouse and man, Foxq1 and FOXQ1, were examined. In order to investigate the regulation of the cell specific gene expression the 5’ sequences of both genes were compared. A region of 370 bp showed a high homology, within this region three binding sites for transcription factors of the Sp familiy were detected by computer analysis. Using transfection experiments and gel shift assays it was shown, that two transcription factors, Sp1 and Sp3, are able to bind to this region and to activate a reporter gene. Additionally it was shown that at least one negatively regulating factor must take part in the regulation of both genes. Northern blot analyses showed a strong expression of FOXQ1 in human stomach and other endodermal tissues. An overexpression of FOXQ1 in carcinoma cell lines was confirmed by investigation of tumor tissue from lung and colon. In order to determine the cell specific expression of Foxq1, in situ hybridization on sections of adult mouse stomach were performed. Foxq1 expression was seen in zymogenic and pre-zymogenic cells. In order to determine the function of the Foxq1 gen, a knock out mouse should be generated. For that purpose a knock out construct was created and transfected in Embryonic Stem (ES) cells. In three ES clones a homologous recombination took place." @default.
- W879561210 created "2016-06-24" @default.
- W879561210 creator A5013460185 @default.
- W879561210 date "2022-02-20" @default.
- W879561210 modified "2023-10-14" @default.
- W879561210 title "Promotoranalyse und Expressionsstudien der murinen und humanen fork head homologen Gene Foxq1 und FOXQ1" @default.
- W879561210 cites W1228798347 @default.
- W879561210 cites W1517480469 @default.
- W879561210 cites W1529788780 @default.
- W879561210 cites W1576747862 @default.
- W879561210 cites W1650504959 @default.
- W879561210 cites W1744230361 @default.
- W879561210 cites W1799405090 @default.
- W879561210 cites W1817548159 @default.
- W879561210 cites W1844312938 @default.
- W879561210 cites W186732618 @default.
- W879561210 cites W1920701843 @default.
- W879561210 cites W1947715267 @default.
- W879561210 cites W1955892023 @default.
- W879561210 cites W1965267927 @default.
- W879561210 cites W1965733949 @default.
- W879561210 cites W1965979273 @default.
- W879561210 cites W1966312815 @default.
- W879561210 cites W1967928127 @default.
- W879561210 cites W1968215541 @default.
- W879561210 cites W1973755623 @default.
- W879561210 cites W1975920595 @default.
- W879561210 cites W1978428628 @default.
- W879561210 cites W1979342595 @default.
- W879561210 cites W1979701027 @default.
- W879561210 cites W1979867623 @default.
- W879561210 cites W1979933285 @default.
- W879561210 cites W1981147791 @default.
- W879561210 cites W1983026860 @default.
- W879561210 cites W1986868728 @default.
- W879561210 cites W1990028456 @default.
- W879561210 cites W1990283480 @default.
- W879561210 cites W1993243592 @default.
- W879561210 cites W1993475336 @default.
- W879561210 cites W1993681905 @default.
- W879561210 cites W1995269929 @default.
- W879561210 cites W1996151007 @default.
- W879561210 cites W1998625801 @default.
- W879561210 cites W1999527718 @default.
- W879561210 cites W2003028861 @default.
- W879561210 cites W2004159494 @default.
- W879561210 cites W2005144583 @default.
- W879561210 cites W200647492 @default.
- W879561210 cites W2007987759 @default.
- W879561210 cites W2012006105 @default.
- W879561210 cites W2012116939 @default.
- W879561210 cites W2014757100 @default.
- W879561210 cites W2017338099 @default.
- W879561210 cites W2019410656 @default.
- W879561210 cites W2019994371 @default.
- W879561210 cites W2025723633 @default.
- W879561210 cites W2025921655 @default.
- W879561210 cites W2026962630 @default.
- W879561210 cites W2027216583 @default.
- W879561210 cites W2027694148 @default.
- W879561210 cites W2030565157 @default.
- W879561210 cites W2030621682 @default.
- W879561210 cites W2030688236 @default.
- W879561210 cites W2030805070 @default.
- W879561210 cites W2031748375 @default.
- W879561210 cites W2033614517 @default.
- W879561210 cites W2035913301 @default.
- W879561210 cites W2037100222 @default.
- W879561210 cites W2039309643 @default.
- W879561210 cites W2040016657 @default.
- W879561210 cites W2041233862 @default.
- W879561210 cites W2042390149 @default.
- W879561210 cites W2042663852 @default.
- W879561210 cites W2045115524 @default.
- W879561210 cites W2047203795 @default.
- W879561210 cites W2049019670 @default.
- W879561210 cites W2052734254 @default.
- W879561210 cites W2053387942 @default.
- W879561210 cites W2054333952 @default.
- W879561210 cites W2054364851 @default.
- W879561210 cites W2055124184 @default.
- W879561210 cites W2058682074 @default.
- W879561210 cites W2059222296 @default.
- W879561210 cites W2060116181 @default.
- W879561210 cites W2060646272 @default.
- W879561210 cites W2062036642 @default.
- W879561210 cites W2063361315 @default.
- W879561210 cites W2063450941 @default.
- W879561210 cites W2064879068 @default.
- W879561210 cites W2067513896 @default.
- W879561210 cites W2068577315 @default.
- W879561210 cites W2068914231 @default.
- W879561210 cites W2070298717 @default.
- W879561210 cites W2071590821 @default.
- W879561210 cites W2072897152 @default.
- W879561210 cites W2079248815 @default.
- W879561210 cites W2081462171 @default.
- W879561210 cites W2085939516 @default.
- W879561210 cites W2087287740 @default.
- W879561210 cites W2088431556 @default.