Matches in SemOpenAlex for { <https://semopenalex.org/work/W879771539> ?p ?o ?g. }
- W879771539 endingPage "425" @default.
- W879771539 startingPage "411" @default.
- W879771539 abstract "Many early studies on penicillin and cephamycin biosynthesis were carried out in Streptomyces clavuligerus, but because of the commercial importance of clavulanic acid, most recent studies have focused on that compound. In particular, genetic engineering to generate improved clavulanic acid producer strains has been a main interest. S. clavuligerus grows and produces secondary metabolites optimally at 28 to 30°C, but it is unusually sensitive to elevated temperature and will not grow above 31 to 32°C. Liquid media employed by research groups studying the production of the various types of β-lactam metabolites produced by S. clavuligerus vary widely. Numerous bioprocess-type studies examining growth medium optimization as a means of improving production of clavulanic acid have appeared in recent years, typically reinforcing the association of soy-based growth medium constituents with high productivity. In S. clavuligerus, biosynthesis begins with the amino acids L-lysine, L-cysteine, and L-valine and proceeds through the synthesis of penicillin and cephalosporin intermediates to give the final cephamycin product. While improvements in productivity can be achieved by increasing production of pathway enzymes, another approach to achieving this is to identify genes encoding critical regulatory proteins and increase their expression levels. More global approaches to improvement of antibiotic production could also be coupled with strategies aimed at the pathway-specific regulators. Effects of greater magnitude are seen when pathway-specific regulators are targeted for overproduction, and combination approaches targeting both global and specific regulators along with individual pathway enzymes for overproduction, together with elimination of competing pathways, will likely yield even greater results." @default.
- W879771539 created "2016-06-24" @default.
- W879771539 creator A5010971731 @default.
- W879771539 date "2014-04-30" @default.
- W879771539 modified "2023-09-23" @default.
- W879771539 title "Genetic Engineering To Regulate Production of Secondary Metabolites in Streptomyces clavuligerus" @default.
- W879771539 cites W1483806268 @default.
- W879771539 cites W1514157228 @default.
- W879771539 cites W1521398910 @default.
- W879771539 cites W175873098 @default.
- W879771539 cites W1793602128 @default.
- W879771539 cites W1820342348 @default.
- W879771539 cites W188830416 @default.
- W879771539 cites W1941339364 @default.
- W879771539 cites W1964884045 @default.
- W879771539 cites W1966062821 @default.
- W879771539 cites W1968134980 @default.
- W879771539 cites W1969217714 @default.
- W879771539 cites W1974107126 @default.
- W879771539 cites W1977865893 @default.
- W879771539 cites W1979492338 @default.
- W879771539 cites W1980460653 @default.
- W879771539 cites W1981660282 @default.
- W879771539 cites W1983327456 @default.
- W879771539 cites W1985420890 @default.
- W879771539 cites W1986496540 @default.
- W879771539 cites W1990658315 @default.
- W879771539 cites W1995995599 @default.
- W879771539 cites W1999523287 @default.
- W879771539 cites W1999686598 @default.
- W879771539 cites W2000168862 @default.
- W879771539 cites W2001882976 @default.
- W879771539 cites W2003516788 @default.
- W879771539 cites W2011886013 @default.
- W879771539 cites W2013090264 @default.
- W879771539 cites W2013395525 @default.
- W879771539 cites W2013712089 @default.
- W879771539 cites W2015150241 @default.
- W879771539 cites W2018002829 @default.
- W879771539 cites W2019269529 @default.
- W879771539 cites W2019982170 @default.
- W879771539 cites W2020353075 @default.
- W879771539 cites W2023950913 @default.
- W879771539 cites W2034933171 @default.
- W879771539 cites W2046624629 @default.
- W879771539 cites W2047064403 @default.
- W879771539 cites W2047242854 @default.
- W879771539 cites W2048878967 @default.
- W879771539 cites W2049644665 @default.
- W879771539 cites W2049673363 @default.
- W879771539 cites W2050803715 @default.
- W879771539 cites W2055374672 @default.
- W879771539 cites W2065130472 @default.
- W879771539 cites W2069257208 @default.
- W879771539 cites W2069640968 @default.
- W879771539 cites W2071123269 @default.
- W879771539 cites W2073459928 @default.
- W879771539 cites W2075244283 @default.
- W879771539 cites W2084910851 @default.
- W879771539 cites W2085391677 @default.
- W879771539 cites W2087768822 @default.
- W879771539 cites W2088021352 @default.
- W879771539 cites W2095063801 @default.
- W879771539 cites W2100497142 @default.
- W879771539 cites W2101852380 @default.
- W879771539 cites W2102450098 @default.
- W879771539 cites W2106601384 @default.
- W879771539 cites W2107713432 @default.
- W879771539 cites W2108153887 @default.
- W879771539 cites W2112855061 @default.
- W879771539 cites W2116432802 @default.
- W879771539 cites W2119005919 @default.
- W879771539 cites W2121809379 @default.
- W879771539 cites W2123722285 @default.
- W879771539 cites W2123815603 @default.
- W879771539 cites W2126104016 @default.
- W879771539 cites W2128040374 @default.
- W879771539 cites W2129349184 @default.
- W879771539 cites W2135246137 @default.
- W879771539 cites W2135462873 @default.
- W879771539 cites W2135692665 @default.
- W879771539 cites W2137753428 @default.
- W879771539 cites W2141162694 @default.
- W879771539 cites W2142500173 @default.
- W879771539 cites W2144067387 @default.
- W879771539 cites W2146179813 @default.
- W879771539 cites W2146741700 @default.
- W879771539 cites W2149632435 @default.
- W879771539 cites W2152183144 @default.
- W879771539 cites W2158942980 @default.
- W879771539 cites W2162624487 @default.
- W879771539 cites W2164133094 @default.
- W879771539 cites W305409628 @default.
- W879771539 doi "https://doi.org/10.1128/9781555816827.ch28" @default.
- W879771539 hasPublicationYear "2014" @default.
- W879771539 type Work @default.
- W879771539 sameAs 879771539 @default.
- W879771539 citedByCount "0" @default.