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- W8797937 abstract "It is shown experimentally that iso-nicotinic acid hydrazide inhibits mycelial production by Candida albicans in vitro and in vivo. Despite this C. albicans given i.v. may still cause death in rabbits unless a loading dose of I.N.A.H. is given previous to the C. albicans injection and i.p. dosage is continued daily for 7 days. Animals protected in this way, nevertheless show small lesions in their kidneys when killed 18 days later. These lesions contain a small number of blastospores and short hyphae and resemble the pyelonephritis-like lesions in the kidneys of animals given sub-lethal doses of C. albicans.By fluorescent microscopy, and by special staining methods, it was shown that ribo-nucleic acid is present throughout the entire length of C. albicans hyphae and is concentrated at the septa and hyphal tip. Since this is also seen in mycelial fungi such as Aspergillus fumigatus it supports the view that C. albicans forms true mycelium and suggests that the mycelial formation may help the fungus to inva..." @default.
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- W8797937 date "1962-01-01" @default.
- W8797937 modified "2023-09-25" @default.
- W8797937 title "Studies of the invasive, mycelial form ofCandida albicans" @default.
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- W8797937 doi "https://doi.org/10.1080/00362176285190081" @default.
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