FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W87990720> ?p ?o ?g. }

• W87990720 abstract "Part I Introduction The specific problem adressed in this thesis is: what is the rational use of theory and experiment in the process of scientific discovery, in theory and in the practice of drug research for Parkinson’s disease? The thesis aims to answer the following specific questions: what is: 1) the structure of a theory?; 2) the process of scientific reasoning?; 3) the route between theory and experiment? In the first part I further discuss issues about rationality in science as introduction to part II, and I present an overview of my case-study of neuropharmacology, for which I interviewed researchers from the Groningen Pharmacy Department, as an introduction to part III. Part II Discovery In this part I discuss three theoretical models of scientific discovery according to studies in the fields of Logic, Cognition, and Computation. In those fields the structure of a theory is respectively explicated as: a set of sentences; a set of associated memory chunks; and as a computer program that can generate the observed data. Rationality in discovery is characterized by: finding axioms that imply observation sentences; heuristic search for a hypothesis, as part of problem solving, by applying memory chunks and production rules that represent skill; and finding the shortest program that generates the data, respectively. I further argue that reasoning in discovery includes logical fallacies, which are neccesary to introduce new hypotheses. I also argue that, while human subjects often make errors in hypothesis evaluation tasks from a logical perspective, these evaluations are rational given a probabilistic interpretation. Part III Neuropharmacology In this last part I discusses my case-study and a model of discovery in a practice of drug research for Parkinson’s disease. I discuss the dopamine theory of Parkinson’s disease and model its structure as a qualitative differential equation. Then I discuss the use and reasons for particular experiments to both test a drug and explore the function of the brain. I describe different kinds of problems in drug research leading to a discovery. Based on that description I distinguish three kinds of reasoning tasks in discovery, inference to: the best explanation, the best prediction and the best intervention. I further demonstrate how a part of reasoning in neuropharmacology can be computationally modeled as qualitative reasoning, and aided by a computer supported discovery system" @default.
• W87990720 created "2016-06-24" @default.
• W87990720 creator A5014672269 @default.
• W87990720 date "2001-01-01" @default.
• W87990720 modified "2023-09-25" @default.
• W87990720 title "Rationality in discovery: a study of logic, cognition, computation and neuropharmacology" @default.
• W87990720 cites W136713756 @default.
• W87990720 cites W1481251089 @default.
• W87990720 cites W1491063609 @default.
• W87990720 cites W1504910957 @default.
• W87990720 cites W1523113848 @default.
• W87990720 cites W1539673806 @default.
• W87990720 cites W1565693361 @default.
• W87990720 cites W1567087244 @default.
• W87990720 cites W1582174699 @default.
• W87990720 cites W1597739853 @default.
• W87990720 cites W1607052939 @default.
• W87990720 cites W1638203394 @default.
• W87990720 cites W1679907412 @default.
• W87990720 cites W175938201 @default.
• W87990720 cites W1896349060 @default.
• W87990720 cites W1910245860 @default.
• W87990720 cites W1982827121 @default.
• W87990720 cites W1996000782 @default.
• W87990720 cites W2008438091 @default.
• W87990720 cites W2009318929 @default.
• W87990720 cites W2010292075 @default.
• W87990720 cites W2011357142 @default.
• W87990720 cites W2012491163 @default.
• W87990720 cites W2012792908 @default.
• W87990720 cites W2017723268 @default.
• W87990720 cites W2024030746 @default.
• W87990720 cites W2027524003 @default.
• W87990720 cites W2027885053 @default.
• W87990720 cites W2028015998 @default.
• W87990720 cites W2029415078 @default.
• W87990720 cites W2035314812 @default.
• W87990720 cites W2053190303 @default.
• W87990720 cites W2053680135 @default.
• W87990720 cites W2056198101 @default.
• W87990720 cites W2060260678 @default.
• W87990720 cites W2060642394 @default.
• W87990720 cites W2060862000 @default.
• W87990720 cites W2065070540 @default.
• W87990720 cites W2075725716 @default.
• W87990720 cites W2081981374 @default.
• W87990720 cites W2087037929 @default.
• W87990720 cites W2089752327 @default.
• W87990720 cites W2097394782 @default.
• W87990720 cites W2105284546 @default.
• W87990720 cites W2115297031 @default.
• W87990720 cites W2120461818 @default.
• W87990720 cites W2134917048 @default.
• W87990720 cites W2135625884 @default.
• W87990720 cites W2137666284 @default.
• W87990720 cites W2143850783 @default.
• W87990720 cites W2152321927 @default.
• W87990720 cites W2152632951 @default.
• W87990720 cites W2162792036 @default.
• W87990720 cites W2167471601 @default.
• W87990720 cites W2172780573 @default.
• W87990720 cites W2245993458 @default.
• W87990720 cites W2317070699 @default.
• W87990720 cites W2321579511 @default.
• W87990720 cites W2321927544 @default.
• W87990720 cites W2479705455 @default.
• W87990720 cites W2488902406 @default.
• W87990720 cites W2502801628 @default.
• W87990720 cites W2503021760 @default.
• W87990720 cites W2575921458 @default.
• W87990720 cites W2583633152 @default.
• W87990720 cites W2753533763 @default.
• W87990720 cites W2796059588 @default.
• W87990720 cites W2911904387 @default.
• W87990720 cites W3148499377 @default.
• W87990720 cites W3162439866 @default.
• W87990720 cites W31970964 @default.
• W87990720 cites W3215907522 @default.
• W87990720 cites W356179080 @default.
• W87990720 cites W36314504 @default.
• W87990720 cites W587310680 @default.
• W87990720 cites W2799101583 @default.
• W87990720 hasPublicationYear "2001" @default.
• W87990720 type Work @default.
• W87990720 sameAs 87990720 @default.
• W87990720 citedByCount "21" @default.
• W87990720 crossrefType "journal-article" @default.
• W87990720 hasAuthorship W87990720A5014672269 @default.
• W87990720 hasConcept C111472728 @default.
• W87990720 hasConcept C128188215 @default.
• W87990720 hasConcept C138885662 @default.
• W87990720 hasConcept C154945302 @default.
• W87990720 hasConcept C15744967 @default.
• W87990720 hasConcept C167729594 @default.
• W87990720 hasConcept C169760540 @default.
• W87990720 hasConcept C177264268 @default.
• W87990720 hasConcept C188147891 @default.
• W87990720 hasConcept C199360897 @default.
• W87990720 hasConcept C201717286 @default.
• W87990720 hasConcept C2524010 @default.

• next