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- W88000438 abstract "This chapter presents the basic terminology of ligand-binding experiments and some of the problems of interpretation that can arise. Before defining the terminology used in receptor binding studies, it is necessary to explain briefly the principles of the experimental system used, in vitro, to obtain receptor binding data. Only specific binding gives an indication of the extent to which a ligand interacts with a receptor. Some ligands bind specifically to more than one receptor type—for example, 3H-spiperone labels both dopamine and serotonin receptors in the frontal cortex. The simplicity and power of ligand-binding techniques to identify neurotransmitter receptors in the brain, and in many other tissues, has provided a new method of investigating central nervous system function." @default.
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- W88000438 date "1981-01-01" @default.
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- W88000438 title "Interpretation of radioactive ligand binding to cerebral dopamine receptors" @default.
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