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- W88105652 abstract "Poloxamers (PL) are copolymers A-B-A type consisting of ethylene oxide (EO) and propylene oxide (PO) units in a triblock EOx–POy–EOx arrangement. These copolymers are interesting due to their ability for temperature-dependent gel formation, as a result of their self-assembling in micelles. Several studies have demonstrated the application of the thermoreversible copolymers as drug-delivery systems in order to prolong the drug release, to sustain the effectiveness, and also to reduce local and/or systemic toxicity, connecting the expertise of different research fields such as Biochemistry, Nanotechnology, Biopharmaceutics, Pharmacology, and Toxicology. Then, the purpose of this chapter involves a discussion about PL copolymers in the light of those research fields. The development of one-type or binary PL carriers systems is a function of composition (type of copolymer, differences on EO/PO units number, molecular weight), physicochemical properties (hydrophilic-lipophilic balance, cloud point, critical micellar concentration), and structural parameters such as micellar size, temperature for micelles, and hydrogels assembling. Besides, for focusing on how PL can be useful to achieve sustained drug release it is necessary to consider their pharmacological properties (such as the ability to inhibit the P-glycoprotein), in vitro (cytotoxicity or cytoprotection and their mechanisms) and in vivo toxicological evaluation (biocompatibility and regulatory aspects)." @default.
- W88105652 created "2016-06-24" @default.
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- W88105652 date "2013-09-28" @default.
- W88105652 modified "2023-10-01" @default.
- W88105652 title "Poloxamers as Drug-Delivery Systems: Physicochemical, Pharmaceutical, and Toxicological Aspects" @default.
- W88105652 cites W1966044123 @default.
- W88105652 cites W1966139629 @default.
- W88105652 cites W1966345384 @default.
- W88105652 cites W1968261193 @default.
- W88105652 cites W1969604041 @default.
- W88105652 cites W1976302635 @default.
- W88105652 cites W1978210381 @default.
- W88105652 cites W1980994785 @default.
- W88105652 cites W1981729153 @default.
- W88105652 cites W1982974605 @default.
- W88105652 cites W1983544050 @default.
- W88105652 cites W1985631236 @default.
- W88105652 cites W1990017773 @default.
- W88105652 cites W1997415215 @default.
- W88105652 cites W1997793475 @default.
- W88105652 cites W1998941050 @default.
- W88105652 cites W2005385354 @default.
- W88105652 cites W2009288962 @default.
- W88105652 cites W2009571959 @default.
- W88105652 cites W2009621116 @default.
- W88105652 cites W2010699607 @default.
- W88105652 cites W2010908849 @default.
- W88105652 cites W2014098844 @default.
- W88105652 cites W2014676298 @default.
- W88105652 cites W2015346163 @default.
- W88105652 cites W2024610629 @default.
- W88105652 cites W2025292895 @default.
- W88105652 cites W2029822118 @default.
- W88105652 cites W2030863859 @default.
- W88105652 cites W2036455711 @default.
- W88105652 cites W2036459378 @default.
- W88105652 cites W2038039411 @default.
- W88105652 cites W2040004169 @default.
- W88105652 cites W2040426941 @default.
- W88105652 cites W2042400255 @default.
- W88105652 cites W2044225143 @default.
- W88105652 cites W2044368833 @default.
- W88105652 cites W2047623799 @default.
- W88105652 cites W2047909682 @default.
- W88105652 cites W2048268258 @default.
- W88105652 cites W2048536578 @default.
- W88105652 cites W2051200888 @default.
- W88105652 cites W2051332449 @default.
- W88105652 cites W2051950678 @default.
- W88105652 cites W2054087659 @default.
- W88105652 cites W2058343111 @default.
- W88105652 cites W2058509094 @default.
- W88105652 cites W2060239018 @default.
- W88105652 cites W2060907446 @default.
- W88105652 cites W2063844293 @default.
- W88105652 cites W2071724494 @default.
- W88105652 cites W2075621696 @default.
- W88105652 cites W2076089358 @default.
- W88105652 cites W2076670186 @default.
- W88105652 cites W2076841250 @default.
- W88105652 cites W2080779366 @default.
- W88105652 cites W2080819464 @default.
- W88105652 cites W2087483515 @default.
- W88105652 cites W2091468237 @default.
- W88105652 cites W2092718522 @default.
- W88105652 cites W2094603130 @default.
- W88105652 cites W2094880914 @default.
- W88105652 cites W2098509550 @default.
- W88105652 cites W2103059492 @default.
- W88105652 cites W2104717900 @default.
- W88105652 cites W2120054799 @default.
- W88105652 cites W2128583478 @default.
- W88105652 cites W2139888553 @default.
- W88105652 cites W2142897044 @default.
- W88105652 cites W2145362882 @default.
- W88105652 cites W2153519151 @default.
- W88105652 cites W2290540040 @default.
- W88105652 cites W3103982839 @default.
- W88105652 doi "https://doi.org/10.1007/978-1-4614-8993-1_13" @default.
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