Matches in SemOpenAlex for { <https://semopenalex.org/work/W88217874> ?p ?o ?g. }
- W88217874 endingPage "1341" @default.
- W88217874 startingPage "1333" @default.
- W88217874 abstract "Abstract An anti-CD3 Fab' x anti-CD13 Fab' bispecific antibody (BsAb) was generated. This BsAb reacted with both CD3+ T cells and CD13+ acute myeloid leukemia (AML) cells. We investigated whether cytokine- stimulated peripheral blood mononuclear cells (PBMC) could lyse patient AML cells after addition of the BsAb. When interleukin-2 (IL-2)- stimulated PBMC were assayed for their cytotoxicity against 51Cr- labeled allogeneic and autologous CD13+ AML cells, their activity was markedly enhanced by the addition of the BsAb. PBMC stimulated with IL- 2 plus anti-CD3 monoclonal antibody (MoAb) showed higher proliferative ability and higher cytotoxicity if this was expressed as lytic units per culture. IL-7-stimulated PBMC also exhibited enhanced cytotoxicity against CD13+ AML cells after addition of the BsAb. Ultrastructurally, CD13+ AML cells incubated with IL-2 plus anti-CD3 MoAb-stimulated PBMC and the BsAb showed apoptotic morphologic changes. A colony assay for AML blast progenitors showed that the colony formation of CD13+ AML cells was inhibited by the addition of autologous IL-2 plus anti-CD3 MoAb-stimulated PBMC, and that this inhibition was further enhanced by the addition of the BsAb. A colony assay for normal bone marrow progenitor cells showed that the addition of autologous IL-2 plus anti- CD3 MoAb-stimulated PBMC and the BsAb inhibited the formation of granulocyte-macrophage colonies and mixed-cell colonies. However, the degree of inhibition was smaller than that for the AML blast colonies. Taken together, these findings suggest that this BsAb may be useful for ex vivo purging of CD13+ AML cells in autologous bone marrow transplantation." @default.
- W88217874 created "2016-06-24" @default.
- W88217874 creator A5002196422 @default.
- W88217874 creator A5003596492 @default.
- W88217874 creator A5003725234 @default.
- W88217874 creator A5016129416 @default.
- W88217874 creator A5018814821 @default.
- W88217874 creator A5025147822 @default.
- W88217874 creator A5028489205 @default.
- W88217874 creator A5032341070 @default.
- W88217874 creator A5040226584 @default.
- W88217874 creator A5088986458 @default.
- W88217874 date "1993-03-01" @default.
- W88217874 modified "2023-09-27" @default.
- W88217874 title "A bispecific antibody enhances cytokine-induced killer-mediated cytolysis of autologous acute myeloid leukemia cells" @default.
- W88217874 cites W1449076744 @default.
- W88217874 cites W1489541744 @default.
- W88217874 cites W1499989626 @default.
- W88217874 cites W1527454180 @default.
- W88217874 cites W1565218273 @default.
- W88217874 cites W1589415602 @default.
- W88217874 cites W1662314942 @default.
- W88217874 cites W168803914 @default.
- W88217874 cites W174442591 @default.
- W88217874 cites W1930932587 @default.
- W88217874 cites W1973007628 @default.
- W88217874 cites W1981239648 @default.
- W88217874 cites W2008448390 @default.
- W88217874 cites W2013930294 @default.
- W88217874 cites W2016254316 @default.
- W88217874 cites W2018821773 @default.
- W88217874 cites W2023236831 @default.
- W88217874 cites W2036275492 @default.
- W88217874 cites W2039375827 @default.
- W88217874 cites W2052853635 @default.
- W88217874 cites W2053104174 @default.
- W88217874 cites W2065272367 @default.
- W88217874 cites W2084646826 @default.
- W88217874 cites W2087934471 @default.
- W88217874 cites W2121028201 @default.
- W88217874 cites W2129207936 @default.
- W88217874 cites W2133114658 @default.
- W88217874 cites W2148855592 @default.
- W88217874 cites W2182432763 @default.
- W88217874 cites W2266365863 @default.
- W88217874 cites W2268837420 @default.
- W88217874 cites W2296526323 @default.
- W88217874 cites W2396033864 @default.
- W88217874 cites W2407682005 @default.
- W88217874 cites W2410224097 @default.
- W88217874 cites W2418441018 @default.
- W88217874 cites W2430174839 @default.
- W88217874 cites W288838515 @default.
- W88217874 cites W86828079 @default.
- W88217874 doi "https://doi.org/10.1182/blood.v81.5.1333.1333" @default.
- W88217874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8095165" @default.
- W88217874 hasPublicationYear "1993" @default.
- W88217874 type Work @default.
- W88217874 sameAs 88217874 @default.
- W88217874 citedByCount "33" @default.
- W88217874 countsByYear W882178742014 @default.
- W88217874 countsByYear W882178742015 @default.
- W88217874 countsByYear W882178742017 @default.
- W88217874 countsByYear W882178742018 @default.
- W88217874 countsByYear W882178742019 @default.
- W88217874 countsByYear W882178742020 @default.
- W88217874 countsByYear W882178742022 @default.
- W88217874 crossrefType "journal-article" @default.
- W88217874 hasAuthorship W88217874A5002196422 @default.
- W88217874 hasAuthorship W88217874A5003596492 @default.
- W88217874 hasAuthorship W88217874A5003725234 @default.
- W88217874 hasAuthorship W88217874A5016129416 @default.
- W88217874 hasAuthorship W88217874A5018814821 @default.
- W88217874 hasAuthorship W88217874A5025147822 @default.
- W88217874 hasAuthorship W88217874A5028489205 @default.
- W88217874 hasAuthorship W88217874A5032341070 @default.
- W88217874 hasAuthorship W88217874A5040226584 @default.
- W88217874 hasAuthorship W88217874A5088986458 @default.
- W88217874 hasBestOaLocation W882178741 @default.
- W88217874 hasConcept C109316439 @default.
- W88217874 hasConcept C114684123 @default.
- W88217874 hasConcept C137061746 @default.
- W88217874 hasConcept C147483822 @default.
- W88217874 hasConcept C153911025 @default.
- W88217874 hasConcept C159654299 @default.
- W88217874 hasConcept C167672396 @default.
- W88217874 hasConcept C185592680 @default.
- W88217874 hasConcept C201750760 @default.
- W88217874 hasConcept C202751555 @default.
- W88217874 hasConcept C203014093 @default.
- W88217874 hasConcept C2777478134 @default.
- W88217874 hasConcept C2778690821 @default.
- W88217874 hasConcept C2778729363 @default.
- W88217874 hasConcept C28328180 @default.
- W88217874 hasConcept C502942594 @default.
- W88217874 hasConcept C542903549 @default.
- W88217874 hasConcept C55493867 @default.
- W88217874 hasConcept C73588182 @default.