FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W8823967> ?p ?o ?g. }

• W8823967 endingPage "817" @default.
• W8823967 startingPage "809" @default.
• W8823967 abstract "Research Article1 March 1988free access The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing. X. Y. Fu X. Y. Fu Department of Biological Sciences, Columbia University, New York, NY 10027. Search for more papers by this author H. Ge H. Ge Department of Biological Sciences, Columbia University, New York, NY 10027. Search for more papers by this author J. L. Manley J. L. Manley Department of Biological Sciences, Columbia University, New York, NY 10027. Search for more papers by this author X. Y. Fu X. Y. Fu Department of Biological Sciences, Columbia University, New York, NY 10027. Search for more papers by this author H. Ge H. Ge Department of Biological Sciences, Columbia University, New York, NY 10027. Search for more papers by this author J. L. Manley J. L. Manley Department of Biological Sciences, Columbia University, New York, NY 10027. Search for more papers by this author Author Information X. Y. Fu1, H. Ge1 and J. L. Manley1 1Department of Biological Sciences, Columbia University, New York, NY 10027. The EMBO Journal (1988)7:809-817https://doi.org/10.1002/j.1460-2075.1988.tb02879.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We have studied the role in pre-mRNA splicing of the nucleotide sequence preceding the SV40 early region 3′ splice site. Somewhat surprisingly, neither the pyrimidine at the highly conserved −3 position, nor the polypyrimidine stretch that extends from −5 to −15, relative to the 3′ splice site, were found to be required for efficient splicing. Mutations that delete this region or create polypurine insertions at position −2 had no significant effects on the efficiency of SV40 early pre-mRNA splicing in vivo or in vitro. Interestingly, however, the pyrimidine content of this region had substantial effects on the alternative splicing pattern of this pre-mRNA in vivo. Mutations that increased the number of pyrimidine residues resulted in more efficient utilization of the large T antigen mRNA 5′ splice site relative to the small t 5′ splice site, while mutations that increased the purine content enhanced small t mRNA splicing. A possible molecular mechanism for these findings, as well as a model that proposes a role for the polypyrimidine stretch in alternative splicing, are discussed. Previous ArticleNext Article Volume 7Issue 31 March 1988In this issue RelatedDetailsLoading ..." @default.
• W8823967 created "2016-06-24" @default.
• W8823967 creator A5024633873 @default.
• W8823967 creator A5065837805 @default.
• W8823967 creator A5075369042 @default.
• W8823967 date "1988-03-01" @default.
• W8823967 modified "2023-10-12" @default.
• W8823967 title "The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing." @default.
• W8823967 cites W107731324 @default.
• W8823967 cites W1270370721 @default.
• W8823967 cites W1558516755 @default.
• W8823967 cites W1823586796 @default.
• W8823967 cites W1864764602 @default.
• W8823967 cites W1905789932 @default.
• W8823967 cites W1941188086 @default.
• W8823967 cites W1965051773 @default.
• W8823967 cites W1969600436 @default.
• W8823967 cites W1971981203 @default.
• W8823967 cites W1974479832 @default.
• W8823967 cites W1975642325 @default.
• W8823967 cites W1977542860 @default.
• W8823967 cites W1978020758 @default.
• W8823967 cites W1980428104 @default.
• W8823967 cites W1983230358 @default.
• W8823967 cites W1990823895 @default.
• W8823967 cites W1993243592 @default.
• W8823967 cites W1993725313 @default.
• W8823967 cites W2000713154 @default.
• W8823967 cites W2001318760 @default.
• W8823967 cites W2008139645 @default.
• W8823967 cites W2017296679 @default.
• W8823967 cites W2021917091 @default.
• W8823967 cites W2029153838 @default.
• W8823967 cites W2044328627 @default.
• W8823967 cites W2053517688 @default.
• W8823967 cites W2054234926 @default.
• W8823967 cites W2060578134 @default.
• W8823967 cites W2065983662 @default.
• W8823967 cites W2074427164 @default.
• W8823967 cites W2076983675 @default.
• W8823967 cites W2078119356 @default.
• W8823967 cites W2079622220 @default.
• W8823967 cites W2080119769 @default.
• W8823967 cites W2080458798 @default.
• W8823967 cites W2081132215 @default.
• W8823967 cites W2088167128 @default.
• W8823967 cites W2094972420 @default.
• W8823967 cites W2112590565 @default.
• W8823967 cites W2123882323 @default.
• W8823967 cites W2152848856 @default.
• W8823967 cites W2158290831 @default.
• W8823967 cites W2166256336 @default.
• W8823967 cites W246524095 @default.
• W8823967 cites W2745627398 @default.
• W8823967 doi "https://doi.org/10.1002/j.1460-2075.1988.tb02879.x" @default.
• W8823967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/454396" @default.
• W8823967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2840286" @default.
• W8823967 hasPublicationYear "1988" @default.
• W8823967 type Work @default.
• W8823967 sameAs 8823967 @default.
• W8823967 citedByCount "99" @default.
• W8823967 countsByYear W88239672013 @default.
• W8823967 countsByYear W88239672020 @default.
• W8823967 crossrefType "journal-article" @default.
• W8823967 hasAuthorship W8823967A5024633873 @default.
• W8823967 hasAuthorship W8823967A5065837805 @default.
• W8823967 hasAuthorship W8823967A5075369042 @default.
• W8823967 hasBestOaLocation W88239671 @default.
• W8823967 hasConcept C104317684 @default.
• W8823967 hasConcept C105580179 @default.
• W8823967 hasConcept C144024400 @default.
• W8823967 hasConcept C161191863 @default.
• W8823967 hasConcept C194583182 @default.
• W8823967 hasConcept C29595303 @default.
• W8823967 hasConcept C2992077199 @default.
• W8823967 hasConcept C3018669867 @default.
• W8823967 hasConcept C41008148 @default.
• W8823967 hasConcept C54355233 @default.
• W8823967 hasConcept C54458228 @default.
• W8823967 hasConcept C67705224 @default.
• W8823967 hasConcept C70721500 @default.
• W8823967 hasConcept C72994624 @default.
• W8823967 hasConcept C86803240 @default.
• W8823967 hasConceptScore W8823967C104317684 @default.
• W8823967 hasConceptScore W8823967C105580179 @default.
• W8823967 hasConceptScore W8823967C144024400 @default.
• W8823967 hasConceptScore W8823967C161191863 @default.
• W8823967 hasConceptScore W8823967C194583182 @default.
• W8823967 hasConceptScore W8823967C29595303 @default.
• W8823967 hasConceptScore W8823967C2992077199 @default.
• W8823967 hasConceptScore W8823967C3018669867 @default.
• W8823967 hasConceptScore W8823967C41008148 @default.
• W8823967 hasConceptScore W8823967C54355233 @default.
• W8823967 hasConceptScore W8823967C54458228 @default.
• W8823967 hasConceptScore W8823967C67705224 @default.
• W8823967 hasConceptScore W8823967C70721500 @default.
• W8823967 hasConceptScore W8823967C72994624 @default.
• W8823967 hasConceptScore W8823967C86803240 @default.

• next