FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W88244701> ?p ?o ?g. }

• W88244701 endingPage "598" @default.
• W88244701 startingPage "587" @default.
• W88244701 abstract "Murine thioglycolate-induced peritoneal macrophages (MPMs) and the murine RAW264.7 macrophage-like cell line (RAW cells) constitutively produce vascular endothelial growth factor (VEGF). VEGF production is increased under hypoxic conditions or after cell activation with interferon-gamma (IFNgamma) and endotoxin (lipopolysaccharide, LPS). In contrast, tumor necrosis factor-alpha is produced only by IFNgamma/LPS-activated cells. Lactate (25 mmol/L) does not increase VEGF production by these cells. However, hypoxia, lactate, and IFNgamma/LPS-activated MPMs express angiogenic activity, whereas normoxic, nonactivated MPMs do not. Lack of angiogenic activity is not due to an antiangiogenic factor(s) in the medium of these cells. Angiogenic activity produced by hypoxia and lactate-treated MPMs is neutralized by anti-VEGF antibody, which also neutralizes most of the angiogenic activity produced by IFNgamma/LPS-activated MPMs. The inducible nitric oxide synthase inhibitors Ng-nitro-L-arginine-methyl ester (1.5 mmol/L) and aminoguanidine (1 mmol/L) block production of angiogenic activity by MPMs and RAW cells. In RAW cells, Ng-nitro-L-arginine-methyl ester and AG block IFNgamma/LPS-activated, but not constitutive, VEGF production, whereas in MPMs, neither constitutive nor IFNgamma/LPS-activated VEGF synthesis is affected. Synthesis of tumor necrosis factor-alpha is also unaffected. In contrast to normoxic, nonactivated MPMs, inducible nitric oxide synthase-inhibited, IFNgamma/LPS-activated MPMs produce an antiangiogenic factor(s). We conclude that VEGF is a major contributor to macrophage-derived angiogenic activity, and that activation by hypoxia, lactate, or IFNgamma/LPS switches macrophage-derived VEGF from a nonangiogenic to an angiogenic state. This switch may involve a posttranslational modification of VEGF, possibly by the process of ADP-ribosylation. ADP-ribosylation by MPM cytosolic extracts or by cholera toxin switches rVEGF165 from an angiogenic to a nonangiogenic state. In IFNgamma/LPS-activated MPMs, the inducible nitric oxide synthase-dependent pathway also regulates the expression of an antiangiogenic factor(s) that antagonizes the bioactivity of VEGF and provides an additional regulatory pathway controlling the angiogenic phenotype of macrophages." @default.
• W88244701 created "2016-06-24" @default.
• W88244701 creator A5040110369 @default.
• W88244701 creator A5045105854 @default.
• W88244701 creator A5053008196 @default.
• W88244701 creator A5077100007 @default.
• W88244701 date "1998-08-01" @default.
• W88244701 modified "2023-10-14" @default.
• W88244701 title "Production of Vascular Endothelial Growth Factor by Murine Macrophages" @default.
• W88244701 cites W1486423248 @default.
• W88244701 cites W1500910904 @default.
• W88244701 cites W1517718326 @default.
• W88244701 cites W1523151859 @default.
• W88244701 cites W1528762007 @default.
• W88244701 cites W1536635467 @default.
• W88244701 cites W1562579211 @default.
• W88244701 cites W1573946811 @default.
• W88244701 cites W1589090830 @default.
• W88244701 cites W1593536118 @default.
• W88244701 cites W1594268419 @default.
• W88244701 cites W19052207 @default.
• W88244701 cites W1966018566 @default.
• W88244701 cites W1972438151 @default.
• W88244701 cites W1973893754 @default.
• W88244701 cites W1983763042 @default.
• W88244701 cites W1987380856 @default.
• W88244701 cites W1987399881 @default.
• W88244701 cites W1999223106 @default.
• W88244701 cites W2000000541 @default.
• W88244701 cites W2002209097 @default.
• W88244701 cites W2004348481 @default.
• W88244701 cites W2005961677 @default.
• W88244701 cites W2015344488 @default.
• W88244701 cites W2026530967 @default.
• W88244701 cites W2029790299 @default.
• W88244701 cites W2038449972 @default.
• W88244701 cites W2038778872 @default.
• W88244701 cites W2039611537 @default.
• W88244701 cites W2051101992 @default.
• W88244701 cites W2053060309 @default.
• W88244701 cites W2057106552 @default.
• W88244701 cites W2058587734 @default.
• W88244701 cites W2059322719 @default.
• W88244701 cites W2067011026 @default.
• W88244701 cites W2123840402 @default.
• W88244701 cites W2136989771 @default.
• W88244701 cites W2159133324 @default.
• W88244701 cites W2160997491 @default.
• W88244701 cites W2261405959 @default.
• W88244701 cites W2297333053 @default.
• W88244701 cites W2311972351 @default.
• W88244701 cites W2401087756 @default.
• W88244701 cites W2417000676 @default.
• W88244701 cites W4245693946 @default.
• W88244701 doi "https://doi.org/10.1016/s0002-9440(10)65601-5" @default.
• W88244701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1852978" @default.
• W88244701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9708818" @default.
• W88244701 hasPublicationYear "1998" @default.
• W88244701 type Work @default.
• W88244701 sameAs 88244701 @default.
• W88244701 citedByCount "283" @default.
• W88244701 countsByYear W882447012012 @default.
• W88244701 countsByYear W882447012013 @default.
• W88244701 countsByYear W882447012014 @default.
• W88244701 countsByYear W882447012015 @default.
• W88244701 countsByYear W882447012016 @default.
• W88244701 countsByYear W882447012017 @default.
• W88244701 countsByYear W882447012018 @default.
• W88244701 countsByYear W882447012019 @default.
• W88244701 countsByYear W882447012020 @default.
• W88244701 countsByYear W882447012021 @default.
• W88244701 countsByYear W882447012022 @default.
• W88244701 countsByYear W882447012023 @default.
• W88244701 crossrefType "journal-article" @default.
• W88244701 hasAuthorship W88244701A5040110369 @default.
• W88244701 hasAuthorship W88244701A5045105854 @default.
• W88244701 hasAuthorship W88244701A5053008196 @default.
• W88244701 hasAuthorship W88244701A5077100007 @default.
• W88244701 hasBestOaLocation W882447011 @default.
• W88244701 hasConcept C104317684 @default.
• W88244701 hasConcept C126322002 @default.
• W88244701 hasConcept C134018914 @default.
• W88244701 hasConcept C153911025 @default.
• W88244701 hasConcept C160450060 @default.
• W88244701 hasConcept C167734588 @default.
• W88244701 hasConcept C17991360 @default.
• W88244701 hasConcept C185592680 @default.
• W88244701 hasConcept C202751555 @default.
• W88244701 hasConcept C203014093 @default.
• W88244701 hasConcept C2777025900 @default.
• W88244701 hasConcept C2777622882 @default.
• W88244701 hasConcept C2778690821 @default.
• W88244701 hasConcept C2778754761 @default.
• W88244701 hasConcept C2779244956 @default.
• W88244701 hasConcept C2780394083 @default.
• W88244701 hasConcept C2780841837 @default.
• W88244701 hasConcept C502942594 @default.
• W88244701 hasConcept C519581460 @default.

• next