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• W88281208 abstract "Research Article1 September 1993free access Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway. G. Weiss G. Weiss Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author B. Goossen B. Goossen Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author W. Doppler W. Doppler Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author D. Fuchs D. Fuchs Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author K. Pantopoulos K. Pantopoulos Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author G. Werner-Felmayer G. Werner-Felmayer Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author H. Wachter H. Wachter Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author M.W. Hentze M.W. Hentze Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author G. Weiss G. Weiss Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author B. Goossen B. Goossen Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author W. Doppler W. Doppler Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author D. Fuchs D. Fuchs Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author K. Pantopoulos K. Pantopoulos Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author G. Werner-Felmayer G. Werner-Felmayer Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author H. Wachter H. Wachter Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author M.W. Hentze M.W. Hentze Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author Author Information G. Weiss1, B. Goossen1, W. Doppler1, D. Fuchs1, K. Pantopoulos1, G. Werner-Felmayer1, H. Wachter1 and M.W. Hentze1 1Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany. The EMBO Journal (1993)12:3651-3657https://doi.org/10.1002/j.1460-2075.1993.tb06039.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Nitric oxide (NO) produced from L-arginine by NO synthases (NOS) is a transmitter known to be involved in diverse biological processes, including immunomodulation, neurotransmission and blood vessel dilatation. We describe a novel role of NO as a signaling molecule in post-transcriptional gene regulation. We demonstrate that induction of NOS in macrophage and non-macrophage cell lines activates RNA binding by iron regulatory factor (IRFs), the central trans regulator of mRNAs involved in cellular iron metabolism. NO-induced binding of IRF to iron-responsive elements (IRE) specifically represses the translation of transfected IRE-containing indicator mRNAs as well as the biosynthesis of the cellular iron storage protein ferritin. These findings define a new biological function of NO and identify a regulatory connection between the NO/NOS pathway and cellular iron metabolism. Previous ArticleNext Article Volume 12Issue 91 September 1993In this issue RelatedDetailsLoading ..." @default.
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• W88281208 date "1993-09-01" @default.
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• W88281208 title "Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway." @default.
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• W88281208 doi "https://doi.org/10.1002/j.1460-2075.1993.tb06039.x" @default.
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