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- W88307321 abstract "The single human gene for muscle-specific enolase was isolated and its structure was characterized, from which the mature mRNA transcript and encoded protein were also deduced. The gene contains 12 exons, spans approx. 6 kb and encodes a protein of 433 residues. The gene structure is similar to that found for the rat neuron-specific enolase gene, and the deduced protein aligns precisely with other enolase sequences, including the sequence of the only published crystallized enolase, yeast eno-1. The 5' boundary of the gene includes a 5' non-coding exon and is characterized by an upstream TATA-like box and CpG-rich region. This region contains potential recognition motifs for general transcriptional regulation involving Sp1, activator protein 1 and 2, CCAAT box transcription factor/nuclear factor I and cyclic AMP, and for muscle-specific transcriptional regulation involving a CC(A + T-rich)6GG box, M-CAT-box CAATCCT and two myocyte-specific enhancer-binding factor 1 boxes." @default.
- W88307321 created "2016-06-24" @default.
- W88307321 creator A5013974398 @default.
- W88307321 creator A5033778141 @default.
- W88307321 date "1991-04-15" @default.
- W88307321 modified "2023-10-15" @default.
- W88307321 title "Molecular structure of the human muscle-specific enolase gene (<i>ENO3</i>)" @default.
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- W88307321 doi "https://doi.org/10.1042/bj2750427" @default.
- W88307321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1150071" @default.
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