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- W88321619 abstract "Abstract B cells are known to use their signaling mechanism to recognize antigens over a wide range of affinities (10 6 - 10 10 M -1) and generate a graded response that depends on the affinity of antigen binding, a phenomenon known as affinity discrimination. However, the molecular mechanism behind such affinity discrimination is not clear. We have developed a computational model of B cell signaling that reveals that a minimum threshold time of BCR-antigen binding is needed for such affinity discrimination to occur. For a given antigenic affinity, our numerical experiments give rise to stochastically varying levels of activated signaling molecules, such as phosphorylated BCR ITAMs and Syk molecules, as is the case in single cell experiments. Recent experiments have revealed that B cell signaling is coupled with the immunological synapse pattern - an ordered protein segregation structure consisting of BCR/Antigen and LFA-1/ICAM-1 molecules that forms at the cell-cell contact area. We used our Monte Carlo computer model to show that synapse formation modulates the affinity discrimination in B cells." @default.
- W88321619 created "2016-06-24" @default.
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- W88321619 date "2009-04-01" @default.
- W88321619 modified "2023-10-18" @default.
- W88321619 title "Monte Carlo model elucidates mechanisms of B cell affinity discrimination and its modulation by B cell immune synapse formation (34.1)" @default.
- W88321619 doi "https://doi.org/10.4049/jimmunol.182.supp.34.1" @default.
- W88321619 hasPublicationYear "2009" @default.
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